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451 labs · 35 student voices
Takashi Miki, Professor
0 student voices
The Metabolic Physiology Lab studies how glucose and energy metabolism are regulated. Using molecular biology and developmental engineering approaches, the lab analyzes biological phenomena at the molecular, cellular, organ, and whole-body levels. The lab approaches glucose metabolism from two sides: how insulin, which lowers blood glucose, is secreted from pancreatic β cells, and how insulin acts in peripheral tissues. The lab aims to clarify the pathophysiology of metabolic diseases such as diabetes and obesity and to establish new treatments.
Keiichiro Ishiguro, Professor
0 student voices
The Disease and Life Medicine Lab studies the development of germ cells, the precursors of eggs and sperm, and the mechanisms of meiosis. Based on mouse molecular genetics, the lab combines biochemical methods, mass spectrometry, omics analysis using next-generation sequencing, and image analysis. Using factors that determine the initiation of meiosis as clues, the lab investigates how meiosis and germ cell development are coordinated. The lab aims to clarify the causes of infertility and to generate basic knowledge that can bridge to clinical application.
Tetsuichiro Saito, Professor
0 student voices
The Developmental and Regenerative Medicine Lab studies how the nervous system is formed. Most neurons are generated during the fetal period, after which neural stem cells become able to generate only a limited range of cell types. The lab studies the mechanisms that operate in young neural stem cells and explores ways to halt their aging or rejuvenate them. The lab aims to build a molecular foundation for advancing regenerative medicine and to lead to the development of new therapies.
Hiroshi Nakajima, Professor
0 student voices
The Allergy and Clinical Immunology Lab studies allergic diseases such as bronchial asthma, as well as autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. The lab aims to uncover the mechanisms of these diseases at the molecular level and to develop treatments. Working as one with the Department of Allergy and Clinical Rheumatology at Chiba University Hospital, the lab investigates questions arising from clinical practice using the methods of molecular and cell biology. The lab believes that narrowing the gap between basic immunology and clinical immunology is the path to developing curative therapies.
Motoko Kimura, Professor
0 student voices
The Experimental Immunology Lab studies the mechanisms of the immune system, with T cells as its main subject. It has become clear that T cells not only eliminate foreign substances such as pathogens and tumors but also repair tissue damaged by inflammation and maintain tissue homeostasis. Immunity is thought to be not merely a mechanism for eliminating pathogens but one that is essential for maintaining homeostasis of the whole body. The lab aims to discover immune systems that are not yet known and to use them to control disease.
Kiyoshi Hirahara, Professor
0 student voices
The Immune Development Lab studies how the immune system is involved in forming the pathology of various diseases. Immunity not only protects against infections but is also involved in intractable diseases such as hay fever, bronchial asthma, food allergy, and collagen diseases. It has also become clear that immunity is deeply involved in the pathology of lifestyle-related diseases such as cancer and diabetes. The lab aims to develop new treatments for intractable diseases that currently have no therapy.
Atsushi Kaneda, Professor
0 student voices
The Molecular Oncology Lab studies how cancer arises through the epigenome, the information carried by modifications attached to the genome. Cells with the same genome can behave in many different ways because the epigenome regulates which genes are used. Environmental factors such as infection and inflammation, as well as metabolic abnormalities, alter the epigenome, and when these abnormalities accumulate they are deeply involved in the development and progression of cancer. The lab carries out research that leads to diagnosing the risk of developing cancer and to building strategies for treatment and prevention.
Haruhiko Koseki, Professor
0 student voices
The Cellular and Molecular Medicine Lab studies epigenetic mechanisms that determine whether genes are switched on or off. It has become clear that these mechanisms are essential for the development of the body and for maintaining the state of fully formed organs. The lab operates as the Immune Organ Formation Research Team (Yokohama) of the RIKEN Center for Integrative Medical Sciences, and accepts graduate students through the cooperative graduate school program. It combines genetics, biochemistry, and informatics in its analyses, and also works on developing cancer therapy using immune cells made from iPS cells.
Junji Kobayashi, Project Professor
0 student voices
The Endocrinology, Metabolism, and Geriatric Medicine Lab studies diabetes and other metabolic diseases, endocrine diseases, and aging. Because there is still no fundamental treatment for diabetes, the lab uses basic research to clarify the underlying causes of its onset and the mechanisms by which complications occur. In clinical research as well, it analyzes disease pathology from various perspectives and aims to generate new evidence. Through collaborations in Japan and abroad, it also investigates from a molecular perspective hereditary progeroid syndromes such as Werner syndrome, severe obesity, and diseases of the adrenal glands and pituitary.
Emiko Sakaida, Professor
0 student voices
The Hematology Lab studies hematopoietic disorders such as leukemia, malignant lymphoma, and multiple myeloma. Valuing the perspective of physicians who treat blood diseases, the lab aims to improve patients' prognosis and to conquer these diseases. Hematology has close ties between basic research and clinical practice, so findings from basic research can readily be brought back to patients. The lab works on education and on building an environment in which both clinical and basic research strengths are maximized.
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