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Cellular and Molecular Medicine Lab
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The lab approaches development and cancer therapy through the mechanisms that switch genes on and off.
AboutAbout the lab
Reading development and disease through gene switching.
The Cellular and Molecular Medicine Lab studies epigenetic mechanisms that determine whether genes are switched on or off.
It has become clear that these mechanisms are essential for the development of the body and for maintaining the state of fully formed organs.
The lab operates as the Immune Organ Formation Research Team (Yokohama) of the RIKEN Center for Integrative Medical Sciences, and accepts graduate students through the cooperative graduate school program.
It combines genetics, biochemistry, and informatics in its analyses, and also works on developing cancer therapy using immune cells made from iPS cells.
Key terms
- Epigenetics
- A mechanism that determines whether genes are on or off through marks on DNA, or on the proteins it is wrapped around, without changing the DNA sequence.
- Polycomb group
- A set of proteins that keep the function of developmental genes repressed. They work by forming several complexes.
- DNA methylation
- The attachment of small marks (methyl groups) to parts of DNA. Genes at the marked sites become harder to read.
- NKT cells
- A type of immune cell. They attack cancer cells and awaken other immune cells.
NewsLab news
The effect of a new cell therapy using iPS-NKT cells was confirmed in collaboration with the Faculty of Medicine
Results of an investigator-initiated clinical trial administering iPS-NKT cells to head and neck cancer were announced with Chiba University Hospital
The mechanism of transcriptional activation through the degradation of a Polycomb complex was elucidated (Molecular Cell)
A biomarker for atopic dermatitis was discovered in collaboration with Keio University and others
ResearchResearch themes
The lab studies how epigenetic transcriptional regulation is involved in development and in maintaining the state of organs. It investigates the mechanisms of Polycomb group proteins and DNA methylation by combining genetics, biochemistry, and informatics.
*Illustrative imageHow Polycomb Group Proteins Gather on DNA
Polycomb group proteins bind to unmethylated CpG sequences. Using genetic methods, the lab searches for the molecules that control this binding and for the factors that help Polycomb complexes gather in coordination with one another.
*Illustrative imageHow DNA Methylation Is Maintained
Methylated CpG sequences are targets of NP95/UHRF1 and DNMT1. Regarding how NP95 binds to sites of DNA replication and maintains methylation, the lab has found new molecules that control this binding and is investigating their functions.
*Illustrative imageControl of DNA Replication Timing
Focusing on the timing at which gene-rich regions (euchromatin) are replicated, the lab searches for new epigenomic factors involved in controlling it.
*Illustrative imageCancer Immunotherapy Using iPS Cells
In addition to running the animal facility at the Yokohama campus and developing and preserving new genetic resources, the lab pursues research toward developing cancer immunotherapy using NKT cells derived from iPS cells.
MembersFaculty
The members of the Cellular and Molecular Medicine Lab (RIKEN Immune Organ Formation Research Team) consist of faculty members, researchers and special postdoctoral researchers, technical staff, doctoral students, and trainees.
- ProfessorHaruhiko Koseki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Molecular Biology Laboratory, reflections - geograph.org.uk - 3763234” John Sutton / CC BY-SA 2.0 (cropped)
- How Polycomb Group Proteins Gather on DNA: “DNA-RNA-Protein-complex” Tyler Savitski / CC BY-SA 4.0 (cropped)
- How DNA Methylation Is Maintained: “DNA methylation” Christoph Bock, Max Planck Institute for Informatics / CC BY-SA 3.0 (cropped)
- Control of DNA Replication Timing: “XBio illustration – DNA Replication Fork” explorebiology / CC BY 4.0 (cropped)
- Cancer Immunotherapy Using iPS Cells: “A cell culture plate with induced pluripotent stem cells ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Immune Cell Medicine Lab): “Лаборант готовит индивидуальный иммунологический препарат против рака из крови пациента” Иоанна Чернова / CC BY 4.0 (cropped)
- Related lab (Innovative Regenerative Medicine Lab): “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Immune Development Lab): “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Hematology Lab): “Connective Tissue Human Blood Leukocyte Survey ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
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