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Disease and Life Medicine Lab
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The lab explores the mechanisms of meiosis, the cell division that occurs when eggs and sperm are formed.
AboutAbout the lab
What sets mitosis and meiosis apart
The Disease and Life Medicine Lab studies the development of germ cells, the precursors of eggs and sperm, and the mechanisms of meiosis.
Based on mouse molecular genetics, the lab combines biochemical methods, mass spectrometry, omics analysis using next-generation sequencing, and image analysis.
Using factors that determine the initiation of meiosis as clues, the lab investigates how meiosis and germ cell development are coordinated.
The lab aims to clarify the causes of infertility and to generate basic knowledge that can bridge to clinical application.
Key terms
- Meiosis
- A special cell division that occurs when eggs and sperm are produced, in which the number of chromosomes is halved
- Germ cell
- A cell that becomes an egg or sperm and passes genetic information to the next generation
- Omics analysis
- Analysis that examines genes, proteins, and other molecules comprehensively all at once rather than one by one
NewsLab news
A paper first-authored by Lecturer Shimada was published in the journal Genes & Development
A paper first-authored by Lecturer Kikuchi was accepted by the journal Reproduction
ResearchResearch themes
Based on mouse molecular genetics, the lab combines biochemical methods, mass spectrometry, and omics analysis using next-generation sequencing to explore germ cell development and the mechanisms of meiosis. It pursues six research topics under two overarching questions: what is the essential difference between mitosis and meiosis, and what mechanisms coordinate germ cell development with meiosis?
*Illustrative imageMechanisms of meiotic initiation
The lab studies how germ cells switch from mitosis to meiosis. Focusing on MEIOSIN, a transcriptional activator that plays a decisive role in this switch, it analyzes the genes acting downstream in the ovary and testis.
*Illustrative imageThe meiotic cell cycle
Meiosis is a specialized form of the cell cycle: prophase I lasts a long time, and after meiosis I, cells proceed to meiosis II without passing through S phase. The lab aims to clarify the molecular basis of the differences from mitosis.
*Illustrative imageSex differences in meiosis
The testis has a mechanism that detects errors in meiosis and eliminates abnormal cells, whereas in the ovary meiosis I arrests once before birth. The lab analyzes the mechanisms that regulate these male-female differences using gene-knockout mice.
*Illustrative imageChromosome structure in meiosis
In meiosis I, homologous chromosomes pair and recombine, and chromosome structure becomes specialized in a form very different from that in mitosis. The lab aims to identify new chromosomal factors that build this structure and to clarify the chromosome dynamics unique to meiosis.
MembersFaculty
The Disease and Life Medicine Lab consists of faculty, project researchers, graduate students, and secretaries.As of 2026
- ProfessorKeiichiro Ishiguro
- LecturerKoji Kikuchi
- LecturerRyuki Shimada
- Project Assistant ProfessorYasuhiro Fujiwara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “The Beginning of Life” Vitalii Kyryk / CC BY-SA 4.0 (cropped)
- Mechanisms of meiotic initiation: “Meiose (meiosis)” Gijsz / CC0 (cropped)
- The meiotic cell cycle: “Three cell growth types-el” Three_cell_growth_types.png: Χρήστες της αγγλικής Βικιπαίδειας, συμβουλευτείτε το αρχικό αρχείο. derivative work: Περίεργος (talk) / CC BY-SA 3.0 (cropped)
- Sex differences in meiosis: “Human chromosomes under the microscope 01” Korinna / CC BY 4.0 (cropped)
- Chromosome structure in meiosis: “Synapsis and Crossing Over No Labels” Christinelmiller / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse MOB three color” Matt Valley / Public domain (cropped)
- Related lab (Cognitive Behavioral Physiology Lab): “Brain model 12” John Campbell / CC BY 2.0 (cropped)
- Related lab (Clinical Oncology Lab): “Chemotherapy drug” Larry Ostby (Photographer) / Public domain (cropped)
- Related lab (Advanced Data Medical Science Lab): “Illumina Hiseq 2000 sequencers, BGI Hong Kong sequencing room” Scotted400 / CC BY 3.0 (cropped)
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