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Metabolic Physiology Lab
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The lab investigates the mechanisms that regulate glucose and energy metabolism.
AboutAbout the lab
Uncovering the pathophysiology of diabetes and obesity
The Metabolic Physiology Lab studies how glucose and energy metabolism are regulated.
Using molecular biology and developmental engineering approaches, the lab analyzes biological phenomena at the molecular, cellular, organ, and whole-body levels.
The lab approaches glucose metabolism from two sides: how insulin, which lowers blood glucose, is secreted from pancreatic β cells, and how insulin acts in peripheral tissues.
The lab aims to clarify the pathophysiology of metabolic diseases such as diabetes and obesity and to establish new treatments.
Key terms
- Pancreatic β cell
- A cell in the pancreas that produces and releases insulin, the hormone that lowers blood glucose
- Insulin
- The only hormone in the body that lowers the concentration of glucose in the blood
- Developmental engineering
- A method of creating genetically modified animals to examine the function of a gene at the level of the whole organism
ResearchResearch themes
Using molecular biology and developmental engineering approaches, the lab studies the mechanisms that regulate glucose and energy metabolism. It aims to clarify the intracellular signaling and inter-tissue interactions that govern metabolic regulation, and to gain an integrated understanding by analyzing biological phenomena at each level.
*Illustrative imageInsulin secretion and action
The lab studies how glucose metabolism is regulated by examining insulin, the only hormone that lowers blood glucose, from two angles: the mechanisms that control its secretion from pancreatic β cells, and the mechanisms by which insulin acts to deliver glucose in the blood to peripheral tissues.
*Illustrative imageSensing of energy status
The lab studies how the body's energy status is sensed, and how this in turn regulates feeding and energy expenditure in peripheral tissues.
*Illustrative imageInter-organ networks
The lab studies how pancreatic β cells and insulin-responsive tissues such as the liver, skeletal muscle, and adipocytes regulate glucose and energy metabolism through networks with other organs, including the central nervous system.
MembersFaculty
The Metabolic Physiology Lab consists of faculty, graduate students, and technical assistants.
- ProfessorTakashi Miki
- Associate ProfessorEunyoung Lee
- Assistant ProfessorRyo Hatano
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Insulin glulisine 6GV0 spacefill” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Insulin secretion and action: “Würfelzucker” Dietmar Rabich / CC BY-SA 4.0 (cropped)
- Sensing of energy status: “Soehnle bathroom scales-1430” Raimond Spekking / CC BY-SA 4.0 (cropped)
- Inter-organ networks: “Human Anatomy (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Disease Systems Medicine Lab): “Medical Research Council, Laboratory of Molecular Biology - geograph.org.uk - 3018493” David P Howard / CC BY-SA 2.0 (cropped)
- Related lab (Molecular Pathophysiology and Analysis Lab): “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Related lab (International Allergy and Mucosal Immunology Lab): “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse MOB three color” Matt Valley / Public domain (cropped)
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