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Immune Development Lab
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The lab explores intractable inflammatory diseases through the mechanisms of immunity.
AboutAbout the lab
Approaching diseases with no treatment from the side of immunity.
The Immune Development Lab studies how the immune system is involved in forming the pathology of various diseases.
Immunity not only protects against infections but is also involved in intractable diseases such as hay fever, bronchial asthma, food allergy, and collagen diseases.
It has also become clear that immunity is deeply involved in the pathology of lifestyle-related diseases such as cancer and diabetes.
The lab aims to develop new treatments for intractable diseases that currently have no therapy.
Key terms
- Immune system
- The mechanism that recognizes and eliminates foreign substances that enter the body and cells that have become abnormal.
- Intractable diseases
- Diseases for which no fundamental cure has been found so far.
- Collagen diseases
- A general term for diseases in which the immune system attacks the body itself, causing inflammation in tissues throughout the body.
NewsLab news
Assistant Professor Nemoto and colleagues won a Poster Award at the cSIMVa MCM Kickoff Workshop
An immunostained image of abnormal blood vessels taken in the lab was selected as the cover of Circulation Research
Assistant Professor Nemoto received the 3rd Japan Society for Cytokine Research Encouragement Award
A research paper on ex-tissue-resident memory CD4 T cells was published in Science Advances
A research paper on the induction mechanism of inflammatory tissue-resident memory CD4 T cells was published in Science
ResearchResearch themes
The lab studies how the immune system is involved in forming the pathology of various diseases. It focuses on three areas: elucidating the pathology of intractable inflammatory diseases, understanding the diversity and complexity of the immune system, and the links between the immune system and other biological systems.
*Illustrative imageElucidating the pathology of intractable inflammatory diseases
The lab investigates how immunity creates the pathology in intractable inflammatory diseases that have no treatment. In collaboration with gastroenterology, it showed that pathogenic memory Th2 cells are involved in eosinophilic esophagitis.
*Illustrative imageMultilayered nature and complexity of the immune system
This research aims to understand the multilayered nature and complexity of immune mechanisms. In collaboration with labs and hospitals inside and outside the university, the lab reported that the production of anti-type I IFN antibodies is involved in severe COVID-19.
MembersFaculty
The Immune Development Lab consists of faculty members, researchers, graduate students, technicians, laboratory animal management staff, and administrative assistants.As of 2026
- ProfessorKiyoshi Hirahara
- Project Associate ProfessorDamon Tumes
- Project Associate ProfessorChiaki Iwamura
- Assistant ProfessorMasahiro Nemoto
- Project Assistant ProfessorAtsushi Sasaki
- Project Assistant ProfessorTakahisa Hishiya
- Project Assistant ProfessorKaori Tsuji
- Project Assistant ProfessorTakafumi Takase
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Immunology and Regenerative Medicine Research Laboratory - University of Calcutta - Ballygunge - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Elucidating the pathology of intractable inflammatory diseases: “Histology of an eosinophil in esophageal epithelium” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Multilayered nature and complexity of the immune system: “SARS-CoV-2 (CDC-23311)” CDC/ Alissa Eckert, MS; Dan Higgins, MAM / Public domain (cropped)
- Related lab (Immune Cell Medicine Lab): “Лаборант готовит индивидуальный иммунологический препарат против рака из крови пациента” Иоанна Чернова / CC BY 4.0 (cropped)
- Related lab (Cellular and Molecular Medicine Lab): “Molecular Biology Laboratory, reflections - geograph.org.uk - 3763234” John Sutton / CC BY-SA 2.0 (cropped)
- Related lab (Disease Systems Medicine Lab): “Medical Research Council, Laboratory of Molecular Biology - geograph.org.uk - 3018493” David P Howard / CC BY-SA 2.0 (cropped)
- Related lab (International Allergy and Mucosal Immunology Lab): “Mast Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
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