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Developmental and Regenerative Medicine Lab
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The lab studies how the brain is formed, with the aim of contributing to regenerative medicine.
AboutAbout the lab
From how the brain is built to regenerative medicine
The Developmental and Regenerative Medicine Lab studies how the nervous system is formed.
Most neurons are generated during the fetal period, after which neural stem cells become able to generate only a limited range of cell types.
The lab studies the mechanisms that operate in young neural stem cells and explores ways to halt their aging or rejuvenate them.
The lab aims to build a molecular foundation for advancing regenerative medicine and to lead to the development of new therapies.
Key terms
- Neural stem cell
- A cell that is the source from which many types of neurons are generated
- Dendrite
- A branch-like extension from a neuron that receives information from other cells
- Electroporation
- A method of applying electricity to cells to temporarily open gaps in them and introduce genes and other materials
NewsLab news
A doctoral student received the Outstanding Student Award of the CHIBA Excellent Graduate School for Innovative Medicine and the Outstanding Achievement Award of the Doctoral Human Resource Development Project
Project Lecturer Tanaka received the Encouragement Award at the Chiba Neuroresearch Meeting
ResearchResearch themes
By studying the mechanisms of nervous system development, the lab aims to clarify the higher-order functions of the brain and nervous system. It also aims to build a solid molecular foundation for advancing regenerative medicine and to develop new therapies.
*Illustrative imageRejuvenating neural stem cells
Neural stem cells can initially generate many types of neurons, but the range of types they can generate narrows with aging. The lab has found a gene called Nepro that acts in young neural stem cells, and is studying how it maintains them and the roles of other genes.
*Illustrative imageHow neural networks form
Using an electroporation method for mice that the lab developed itself, the lab showed that the Notch pathway is essential for mitral cells in the olfactory bulb to have a single primary dendrite, and that when this pathway does not work properly, odor information cannot be processed normally.
MembersFaculty
The Developmental and Regenerative Medicine Lab consists of faculty, graduate students, medical student scholars, technical assistants, and administrative assistants.
- ProfessorTetsuichiro Saito
- Project LecturerHiromitsu Tanaka
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mouse MOB three color” Matt Valley / Public domain (cropped)
- Rejuvenating neural stem cells: “Petri Dish with HEK293 (NIH BioArt 653)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- How neural networks form: “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
- Related lab (機能ゲノム学): “3a6p xpo5 ran miRNA” Opabinia regalis / CC BY-SA 3.0 (cropped)
- Related lab (イノベーション再生医学): “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (疾患生命医学): “The Beginning of Life” Vitalii Kyryk / CC BY-SA 4.0 (cropped)
- Related lab (機能形態学): “White Matter Connections Obtained with MRI Tractography” Xavier Gigandet et. al. / CC BY 2.5 (cropped)
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