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Endocrinology, Metabolism, and Geriatric Medicine Lab
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The lab takes on diabetes, endocrine diseases, and the mechanisms of aging.

AboutAbout the lab
From clinical questions to new evidence.
The Endocrinology, Metabolism, and Geriatric Medicine Lab studies diabetes and other metabolic diseases, endocrine diseases, and aging.
Because there is still no fundamental treatment for diabetes, the lab uses basic research to clarify the underlying causes of its onset and the mechanisms by which complications occur.
In clinical research as well, it analyzes disease pathology from various perspectives and aims to generate new evidence.
Through collaborations in Japan and abroad, it also investigates from a molecular perspective hereditary progeroid syndromes such as Werner syndrome, severe obesity, and diseases of the adrenal glands and pituitary.
Key terms
- Cortisol
- A hormone released from the adrenal glands. It is involved in regulating blood glucose and blood pressure, and too much of it can cause disease.
- Diabetic kidney disease
- A complication in which the kidneys are damaged by prolonged diabetes. It accounts for many of the causes of dialysis in Japan.
- Knockout mouse
- A mouse in which the function of a certain gene has been eliminated. It is used to examine the role of that gene in a living animal.
NewsLab news
A paper by Lecturer Suzuki and colleagues was selected as a Featured Article in JCEM Case Reports of the Endocrine Society (USA)
Received the KO Rounds Runners-up Award at the International Congress of Endocrinology and the Annual Meeting of the Japan Endocrine Society
Received the Poster Oral Presentation Award at the Seoul International Congress of Endocrinology and Metabolism
Received an Encouragement Award at the Kanto-Koshinetsu Regional Meeting of the Japan Geriatrics Society
A paper based on a doctoral dissertation was published in the European Journal of Endocrinology
ResearchResearch themes
Diabetes is a widely known common disease, but there is still no fundamental treatment for it. The lab aims to clarify the causes of its onset and the mechanisms of its complications through basic research, and to analyze disease pathology through clinical research, leading to the establishment of preventive methods and the development of new treatments.
*Illustrative imageHow Insulin Lowers Blood Glucose
It is still not well understood which organs insulin acts on, and how, to lower blood glucose. Using a method that examines insulin sensitivity in rodents without anesthesia or restraint, the lab investigates where the impairment lies in obesity and type 2 diabetes.
*Illustrative imageThe Transcription Factor Tcf21 and Diabetic Kidney Disease
Diabetic kidney disease accounts for more than 40% of the causes of dialysis in Japan. Using mice in which Tcf21 is deleted at each stage of development, the lab investigates the role of this gene in kidney development and the mechanism by which it acts protectively against diabetic kidney disease.
*Illustrative imageThe Role of Glutamine Metabolism
The lab focuses on GLS2, a central enzyme of glutamine metabolism whose transcription is activated by p53, known as the guardian of the genome. Using knockout mice and cultured cells, it studies the role of glutamine metabolism in the body and its relationship to disease.
*Illustrative imageInvestigating the Cause of the Adrenal Disease PMAH
The lab has long studied PMAH, a disease in which multiple large nodules form in the adrenal glands and which can cause excessive cortisol secretion. It is now examining how the causative gene ARMC5 forms tumors and disrupts hormone secretion.
MembersFaculty
The members of the Endocrinology, Metabolism, and Geriatric Medicine Lab consist of faculty members, medical staff, graduate students, and project researchers.
- Project ProfessorJunji Kobayashi
- Associate ProfessorYoshiro Maezawa
- Project Associate ProfessorTakahiro Ishikawa
- LecturerSawako Suzuki
- Project LecturerMayumi Shoji
- Project LecturerJunko Matsumoto
- Clinical Lecturer, Assistant ProfessorTakumi Kitamoto
- Clinical Lecturer, Assistant ProfessorShintaro Ide
- Assistant ProfessorJin Kumagai
- Assistant ProfessorHisaya Kato
- Project Assistant ProfessorKazuki Ishiwata
- Project Assistant ProfessorNaoya Teramoto
- Project Assistant ProfessorHidetoshi Ochiai
- Project Assistant ProfessorDaisuke Kinoshita
- Project Assistant ProfessorHiyori Kaneko
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Diabetes health cheack” Ofek Abuhazira / CC BY-SA 4.0 (cropped)
- How Insulin Lowers Blood Glucose: “Laboratory Test Tubes; from a medical laboratory in Abuja, Nigeria” Frankincense Diala / CC0 (cropped)
- The Transcription Factor Tcf21 and Diabetic Kidney Disease: “Dialog-dialysis-machine-b-braun” / CC BY-SA 4.0 (cropped)
- The Role of Glutamine Metabolism: “Glutamine-from-xtal-3D-bs-17” Ben Mills / Public domain (cropped)
- Investigating the Cause of the Adrenal Disease PMAH: “1801 The Endocrine System” OpenStax College / CC BY 3.0 (cropped)
- Related lab (Allergy and Clinical Immunology Lab): “Eosinophils in Peripheral Blood Smear ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Related lab (Molecular Pathophysiology and Analysis Lab): “DNA-Sequencers from Flickr 57080968” Flickr user jurvetson / CC BY 2.0 (cropped)
- Related lab (Innovative Regenerative Medicine Lab): “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Cellular and Molecular Medicine Lab): “Molecular Biology Laboratory, reflections - geograph.org.uk - 3763234” John Sutton / CC BY-SA 2.0 (cropped)
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