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Allergy and Clinical Immunology Lab
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The lab investigates asthma and rheumatoid arthritis from both basic immunology and clinical perspectives.
AboutAbout the lab
Working to overcome refractory immune diseases.
The Allergy and Clinical Immunology Lab studies allergic diseases such as bronchial asthma, as well as autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.
The lab aims to uncover the mechanisms of these diseases at the molecular level and to develop treatments.
Working as one with the Department of Allergy and Clinical Rheumatology at Chiba University Hospital, the lab investigates questions arising from clinical practice using the methods of molecular and cell biology.
The lab believes that narrowing the gap between basic immunology and clinical immunology is the path to developing curative therapies.
Key terms
- Th2 cells
- A type of helper T cell, which directs immune responses. Th2 cells act in the direction of causing allergic inflammation.
- Airway epithelial cells
- Cells that line the inside of the airways. They release substances in response to external stimuli and are also involved in inflammation.
- Gut microbiota
- The community of many bacteria living in the intestine. It also affects the body's immunity and metabolism.
NewsLab news
A case report by a doctoral student was published in Modern Rheumatology Case Reports
A case report from the department was accepted by Modern Rheumatology Case Reports
Research by Clinical Lecturer Tanaka was accepted by ACR Open Rheumatology
A case report from the department was accepted by Frontiers in Immunology
Two review articles by Project Assistant Professor Ida were published in the Japanese journal Ryumachika
ResearchResearch themes
The lab conducts basic and clinical research on allergic and autoimmune diseases. It focuses on research that may soon be useful in clinical practice, and while respecting each member's interests, it takes care to ensure that individual studies are organically connected to one another.
*Illustrative imageElucidating the pathology of refractory asthma
In refractory asthma, treatments targeting Th2 cells are less effective, and neutrophilic inflammation occurs in the airways. The lab has shown that Th17 cells exacerbate allergic inflammation and that Dectin-2 on dendritic cells is essential for their differentiation.
*Illustrative imageAirway epithelium and allergic inflammation
Airway epithelial cells not only act as a physical barrier but also release cytokines in response to allergens, viruses, and air pollutants. The lab is searching for new therapeutic targets by studying the interactions between epithelial cells and immune cells.
*Illustrative imagePathology and treatment strategies for rheumatoid arthritis
Even now that biologics and JAK inhibitors are available, some cases continue to relapse. The lab focuses on the periods when joint inflammation subsides and when it relapses, and investigates the cells and molecular mechanisms at work in each.
*Illustrative imageGut environment and allergy
The gut microbiota and the metabolites they produce in the intestine have been linked to inflammatory bowel disease and autoimmune diseases. The lab is investigating how the gut environment contributes to the onset and exacerbation of allergic diseases.
MembersFaculty
The Allergy and Clinical Immunology Lab consists of faculty members, clinical staff physicians, doctoral students, research students, junior residents, physicians studying abroad, collaborating staff, and technical assistants.
- ProfessorHiroshi Nakajima
- Associate ProfessorKotaro Suzuki
- Associate ProfessorAkira Suto
- Project Associate ProfessorShunsuke Furuta
- LecturerArifumi Iwata
- Clinical LecturerShigeru Tanaka
- Clinical LecturerKazuyuki Meguro
- Project LecturerYuko Maezawa
- Project Assistant ProfessorTakahiro Kageyama
- Assistant ProfessorTakahiro Sugiyama
- Project Assistant ProfessorShunjiro Kurihara
- Project Assistant ProfessorTomoaki Ida
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Eosinophils in Peripheral Blood Smear ( )” Ed Uthman from Houston, TX, USA / CC BY 2.0 (cropped)
- Elucidating the pathology of refractory asthma: “An Asthma patient taking medication using an inhaler” https://www.myupchar.com/en / CC BY-SA 4.0 (cropped)
- Airway epithelium and allergic inflammation: “Luxembourg City - Churchill Square - Air pollution measuring station” Cayambe / CC BY-SA 4.0 (cropped)
- Pathology and treatment strategies for rheumatoid arthritis: “Rheumatoide Arthritis der Hand 65W - CR ap - 001” Hellerhoff / CC BY-SA 4.0 (cropped)
- Gut environment and allergy: “Phosphate solubilizing bacteria cultured in petri dish” Joydeep / CC BY-SA 3.0 (cropped)
- Related lab (Endocrinology, Metabolism, and Geriatric Medicine Lab): “Diabetes health cheack” Ofek Abuhazira / CC BY-SA 4.0 (cropped)
- Related lab (Respiratory Medicine Lab): “CT-Thorax-5.0-B70f-Lungs” Ptrump16 / CC BY-SA 4.0 (cropped)
- Related lab (Experimental Immunology Lab): “T Lymphocyte ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Pediatrics Lab): “Haende-30” Matthias Süßen / CC BY-SA 3.0 (cropped)
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