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Shota Nakamura, Professor
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The Nakamura Lab (Infection Metagenomics Division) studies infectious diseases using next-generation sequencing, structural analysis, and bioinformatics. The lab was founded with the aim of applying metagenomic analysis, which has been used to search for microorganisms in environmental surveys, to develop a diagnostic method that can detect any pathogen simply and quickly. In its January 2023 message, the lab states that understanding infectious diseases requires close study of the relationships among infectious microorganisms, commensal microorganisms, and humans. The lab's English name is Infection Metagenomics, and it is known by the abbreviation iMet.
Yoichiro Nakatani, Professor
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The Nakatani Lab studies the evolutionary records engraved in the genome to better understand the genomic abnormalities that cause human hereditary diseases and cancer. Using interdisciplinary approaches that include evolutionary genetics, oncology, and bioinformatics, the lab works on genome information analysis, multi-omics analysis, and algorithm development. Its main research is evolutionary genomics, which traces vertebrate genome evolution from the genomes of species such as medaka and lamprey, and cancer genome analysis. The lab is part of the Genome Evolution and Medical Science Group in the Division of Bioinformatics, Bioinformatics Center, Research Institute for Microbial Diseases.
Shotaro Yamazaki, Associate Professor
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The Yamazaki Lab, part of the RNA Informatics Group in the Division of Bioinformatics, Bioinformatics Center, Research Institute for Microbial Diseases, aims to understand the mechanisms of gene expression regulation through analysis of information on messenger RNA (mRNA) and to apply that understanding. Proteins in the body are made when DNA information is transcribed into mRNA and then translated. The lab investigates the complex regulatory mechanisms involved in mRNA transcription, degradation, and translation using the latest sequencing technologies and machine learning. The findings are applied to the development of new medical and industrial technologies.
Jumpei Ito, Professor
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The Viral Informatics Group (Ito Lab) researches bioinformatics and AI technologies that contribute to controlling infectious diseases. Since the COVID-19 pandemic, large amounts of viral genetic information and experimental data have become available, and virology has entered the era of big data. The lab is developing AI that predicts viral properties from genome sequences, as well as AI that searches for viruses in wild animals and livestock. Beyond building new technologies, the lab also aims to generate new insights from large-scale data analysis using those technologies.
Tetsuya Tetsuya, Professor
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The Bacterial Infection Division (Tetsuya Lab) studies, based on pathogen genome information, the mechanisms by which pathogens infect hosts and cause symptoms. Centering on Vibrio parahaemolyticus, which lives in seawater, the lab investigates the apparatus that causes food poisoning and how it works. Using next-generation sequencers, the lab finds new pathogens and also aims to clarify how infectious diseases of unknown cause arise. The lab is part of the Research Institute for Microbial Diseases, and accepts graduate students from the Graduate School of Medicine and the Graduate School of Frontier Biosciences.
Takeshi Kobayashi, Professor
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The Viral Immunology Division (Kobayashi Lab) studies viruses of the order Reovirales, such as rotavirus and bat-derived reovirus, and norovirus of the family Caliciviridae. Using reverse genetics, a technique for artificially constructing and manipulating viral genes, the lab investigates how viruses replicate and how they cause disease. The lab is also considering research that puts viruses to use, such as developing virus-based therapeutics and vaccine vectors. The lab is located in the Research Institute for Microbial Diseases, Osaka University, and accepts graduate students from the Graduate School of Medicine and the Graduate School of Frontier Biosciences.
Yoshiharu Matsura, Professor
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The Virus Control Group (Matsura Lab) studies viruses with pandemic potential. Viruses are organisms that can multiply only inside living cells, and to the cell they are unwelcome guests. Focusing on hepatitis C virus, the lab investigates how viruses multiply inside cells, cause disease, and evade the immune system. The lab belongs to the Center for Infectious Disease Education and Research and the Research Institute for Microbial Diseases at the University of Osaka, and brings together people from varied backgrounds such as agriculture, medicine, engineering, and science.
Tetsuya Tetsuya, Professor
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The Malaria Vaccine Development Group (Horii Lab) is developing a highly effective vaccine against falciparum malaria for practical use. At the same time, the lab analyzes the molecular mechanisms of the antigen genes that underpin the vaccine, aiming to apply its findings in vaccine development. Falciparum malaria infects many people worldwide and causes many deaths, and the spread of drug-resistant strains is also a problem. The lab belongs to the Research Center for Intractable Infectious Diseases and conducts its research as the Endowed Department for Malaria Vaccine Development.
Masaharu Iwasaki, Project Associate Professor
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The Emerging Viral Diseases Research Group (Iwasaki Lab) studies emerging viruses, with a focus on Lassa virus. Lassa virus has a high fatality rate, and there is no established treatment or preventive measure. Using approaches from virology, immunology, and RNA biology, the lab aims to elucidate how viruses multiply and how they cause disease. The lab also pursues applied research that uses its findings to develop new diagnostic methods, treatments, and preventive measures.
Kentaro Tsukamoto, Project Associate Professor
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The Zoonotic Bacterial Infections Research Group (Tsukamoto Lab) studies pathogenic bacteria that cause zoonotic infections. Focusing on Bartonella, the cause of cat-scratch disease, the lab investigates why cats do not become ill but humans do (host specificity). The lab focuses on the increase in blood vessels that occurs during infection (angiogenesis) and aims to clarify how factors produced by the bacteria work. The lab accepts graduate students from the Graduate School of Medicine, and welcomes visits from students of any background, including medicine, agriculture, and science.
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