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927 labs · 0 student voices
Shizuo Akira, Project Professor
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The Akira Lab focuses its research on innate immunity. Innate immunity is a defense mechanism of the body that is activated at the earliest stage when pathogenic microorganisms invade, and that acts in triggering inflammatory responses and in establishing adaptive immunity. The lab has studied how pathogens are recognized by receptors such as Toll-like receptors (TLRs), as well as the intracellular signaling pathways involved. It now focuses on immune regulation through mRNA stability, aiming to clarify immunometabolism and the causes of various immune diseases and to establish new therapies.
Hisashi Arase, Professor
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The Immunochemistry Lab studies why the immune system, which evolved to protect the body from infection, can malfunction and cause abnormalities such as autoimmune diseases. The lab focuses on molecules that regulate the function of immune cells and examines how these molecules interact with the body's own molecules and with pathogens. It uses approaches such as genetically modified mice, single-cell analysis, and RNA-seq. The lab aims to uncover the causes behind questions such as why some people develop autoimmune diseases or cancer, and why some people become severely ill from infections.
Yoshiko Murakami, Project Professor
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The Glycan Immunology Lab studies how GPI-anchored proteins on the cell surface are made and what they do. GPI-anchored proteins are proteins attached to the cell membrane by the glycolipid GPI, and they include enzymes, receptors, and adhesion molecules. If GPI is not made in the correct structure and in the necessary amount, a disease called GPI deficiency results, so the lab aims to clarify its pathology and apply this to diagnosis and treatment.
Tetsuya Tetsuya, Professor
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The Immunometabolism Lab studies metabolism and immune cells in the body, where multiple organs work in coordination. The lab examines the role that metabolic signals play inside immune cells, and how immune cells affect whole-body metabolism. It also studies the roles that metabolic signals play in various types of cells. The lab belongs to the Department of Host Defense at the Research Institute for Microbial Diseases.
Eiji Hara, Professor
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The Hara Lab, in the Division of Molecular Biology, studies the relationship between aging and cancer, focusing on the phenomenon of cellular senescence. Cellular senescence is one of the safeguards by which cells stop proliferating when they detect abnormalities, and it acts to suppress cancer. On the other hand, the lab considers that senescent cells accumulating in the body with aging and obesity are one cause of the onset of various inflammatory diseases, including cancer. The lab aims to clarify how cellular senescence occurs and what it does, and to develop methods to control it.
Nobuyuki Takakura, Professor
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The Takakura Lab, in the Division of Signal Transduction, studies how blood vessels form in order to apply the findings to cancer treatment and regenerative medicine. In tissues such as the brain and intestine, tissue-specific stem cells differentiate into the necessary cells to form organs, and blood vessels create the environment that serves as their foundation. The lab has shown that cancer stem cells proliferate by using the environment (niche) created by blood vessels, and is working to develop therapies aimed at a definitive cure for cancer. The lab also accepts people from different fields such as engineering, and encourages interested people to visit the lab at least once.
Ai Kotani, Professor
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The Kotani Lab, in the Division of Infection and Tumor Control, studies hematopoietic malignancies and other diseases caused by Epstein-Barr virus (EBV). The lab aims to carry out its research on two wheels: research aimed at treatment, and the building of new science. Clinical trials based on the lab's research results have been underway since 2023. Graduate students are accepted from the Graduate School of Medicine and the Graduate School of Frontier Biosciences at Osaka University.
Kenji Kamimoto, Professor
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The Kamimoto Lab reconstructs in silico the regulatory circuits of living systems that cells and genes form, drawing on large and complex datasets. From models of life built in silico, the lab aims to decipher the complex rules of biological regulation and to use them for predictive simulation as well. The lab conducts both biological experiments using cultured cells (wet research) and data analysis using AI and machine learning (dry research). It focuses in particular on cancer, aging, stem cell differentiation, and gene regulation and the epigenome.
Masahito Ikawa, Professor
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The Ikawa Lab (Department of Experimental Genome Research) develops tools for analyzing gene function using reproductive engineering and developmental engineering, and studies reproductive biology at the level of the whole organism. The lab explains that methods for examining gene function in whole organisms, and animals whose genes have been artificially manipulated, have come to play a role in disease research and basic biological research. In fertilization research, the lab uses knockout mice and transgenic mice to re-examine long-held established theories. The lab carries out its research in collaboration with the Animal Resource Center for Infectious Diseases and the Center for Genetic Analysis of Biological Responses, both affiliated with the Research Institute for Microbial Diseases, and also supports the production of genetically modified animals through the nonprofit organization Developmental Engineering Research Association.
Daron M. Standley, Professor
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The Standley Lab (Department of Genome Informatics) studies the immune system through both collaboration with experimental researchers and development of bioinformatics software. The lab analyzes the immune repertoire, the collection of receptors carried by B cells and T cells, searching for signatures specific to diseases such as cancer, with the aim of using them for diagnosis. The lab has continued to develop MAFFT, multiple sequence alignment software that aligns and compares biological sequences, since its release in 2002. The lab also studies how biomolecules function based on their structures, in collaboration with experimental researchers.
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