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Zoonotic Bacterial Infections Research Group Tsukamoto Lab
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A lab that investigates how the bacteria causing zoonotic infections interact with their hosts.
AboutAbout the lab
Capturing host–pathogen interactions in zoonotic infections
The Zoonotic Bacterial Infections Research Group (Tsukamoto Lab) studies pathogenic bacteria that cause zoonotic infections.
Focusing on Bartonella, the cause of cat-scratch disease, the lab investigates why cats do not become ill but humans do (host specificity).
The lab focuses on the increase in blood vessels that occurs during infection (angiogenesis) and aims to clarify how factors produced by the bacteria work.
The lab accepts graduate students from the Graduate School of Medicine, and welcomes visits from students of any background, including medicine, agriculture, and science.
Key terms
- zoonosis
- Also called an animal-derived infectious disease; an infection caused by a pathogen carried by animals
- host specificity
- The way the effects of a pathogen differ depending on the host species, as when cats do not become ill but humans do
- angiogenesis
- The phenomenon in which new blood vessels extend like branches from existing blood vessels
NewsLab news
View More ↗ResearchResearch themes
The lab studies how pathogenic bacteria that cause zoonotic infections survive inside the host's body and affect the host. Using Bartonella, a bacterium that infects humans and induces the growth of new blood vessels, as its subject, the lab aims to understand why the way disease develops differs between hosts.
*Illustrative imageBartonella, a bacterium that increases blood vessels
Bartonella henselae, the cause of cat-scratch disease, produces no symptoms in cats but causes disease in humans. To find the reason for this difference, the lab focuses on the increase in blood vessels that the bacterium induces.
*Illustrative imageBafA, a bacterial factor that increases blood vessels
The lab has shown that BafA, a protein produced by Bartonella, acts on VEGFR2, the receptor for VEGF on the surface of vascular endothelial cells, and promotes cell proliferation. Experiments using mice have also shown that it induces angiogenesis.
MembersFaculty
The members of the Tsukamoto Lab consist of faculty, project researchers, project administrative staff, doctoral students, technical assistants, and a Visiting Professor, Visiting Associate Professor, and Visiting Researchers.As of 2026
- Project Associate ProfessorKentaro Tsukamoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “15985 lores” CDC/ Sheila Mitchel / Public domain (cropped)
- Bartonella, a bacterium that increases blood vessels: “Cat scratch disease - low mag” Nephron / CC BY-SA 3.0 (cropped)
- BafA, a bacterial factor that increases blood vessels: “Formation of the new blood vessels 2” Author: Patrycja Kowalska, Foundation of Research and Science Development, Poland Fundacja Badań i Rozwoju Nauki / CC BY 4.0 (cropped)
- Related lab (Pathogenic Bacteria Research Group Abe Lab): “Antimicrobial susceptibility testing (AST) result of Leuconostoc” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Iwasaki Lab): “Lassa Virus” NIAID / CC BY 2.0 (cropped)
- Related lab (Watanabe Lab): “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
- Related lab (Kodama Lab): “E. coli Bacteria ( )” NIAID / CC BY 2.0 (cropped)
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