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Tetsuya Lab
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The lab investigates the mechanisms of infection and disease onset from pathogen genomes.
AboutAbout the lab
Uncovering how infection and disease arise from genome information
The Bacterial Infection Division (Tetsuya Lab) studies, based on pathogen genome information, the mechanisms by which pathogens infect hosts and cause symptoms.
Centering on Vibrio parahaemolyticus, which lives in seawater, the lab investigates the apparatus that causes food poisoning and how it works.
Using next-generation sequencers, the lab finds new pathogens and also aims to clarify how infectious diseases of unknown cause arise.
The lab is part of the Research Institute for Microbial Diseases, and accepts graduate students from the Graduate School of Medicine and the Graduate School of Frontier Biosciences.
Key terms
- Vibrio parahaemolyticus
- A bacterium that lives in seawater. When it infects humans, it causes food poisoning
- T3SS2
- A secretion system that punctures host cells and injects the bacterium's own proteins into them. It is responsible for the virulence of Vibrio parahaemolyticus
- Emerging infectious disease
- A newly recognized infectious disease. A known infectious disease that spreads again is called a re-emerging infectious disease
NewsLab news
Prof. Tetsuya received the Society Award of the Japan Society for Culture Collections for FY2026 (Reiwa 8)
A master's student received the Best Poster Presentation Award at the 22nd 21st Century E. coli Research Meeting
Prof. Tetsuya received the 7th Toyoichi Otahara Prize
A SATREPS joint research project with the National Institute of Bacterial Infections in India has started
The lab received an Outstanding Poster Award at the 99th Meeting of the Japanese Society for Bacteriology
ResearchResearch themes
The Bacterial Infection Division studies, based on genome information, how pathogens infect hosts and cause symptoms. It also develops pathogen detection methods using next-generation sequencers to identify new pathogens, aiming to clarify how infectious diseases of unknown cause develop.
*Illustrative imageMechanisms of infection and disease onset in pathogenic bacteria
Through whole-genome analysis of Vibrio parahaemolyticus, the lab identified T3SS2, a secretion system responsible for its virulence. It also showed that expression of this system's genes is induced by bile, and is advancing analysis of how symptoms arise.
*Illustrative imageDevelopment of diagnostic and pathogen detection methods for infectious diseases
For some emerging and re-emerging infectious diseases, the causative pathogen or the mechanism of onset is unknown. The lab identifies pathogens and causative genes of disease through genome analysis with next-generation sequencers, and develops detection and diagnostic methods.
MembersFaculty
The members of the Bacterial Infection Division (Tetsuya Lab) are faculty, project researchers, doctoral, master's, and undergraduate students, technical assistants, visiting professors and visiting researchers, and secretaries.As of 2026
- ProfessorTetsuya Tetsuya
- Associate ProfessorShigeaki Matsuda
- Assistant ProfessorEiji Ishii
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “TCBS agar plate of Vibrio Cholerae and vibrio parahaemolyticus” Chainwit. / CC BY-SA 4.0 (cropped)
- Mechanisms of infection and disease onset in pathogenic bacteria: “Vibrio parahaemolyticus 01” Photo Credit: Janice Carr Content Providers(s): CDC/ Janice Carr / Public domain (cropped)
- Development of diagnostic and pathogen detection methods for infectious diseases: “Thermal cycler for PCR” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (ウイルス免疫分野 小林研究室): “Multiple rotavirus particles” Dr Graham Beards / CC BY 3.0 (cropped)
- Related lab (ウイルス制御学グループ 松浦研究室): “Hepatitis C” NIH Image Gallery / CC BY 2.0 (cropped)
- Related lab (マラリアワクチン開発研究グループ 堀井研究室): “Plasmodium falciparum smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Related lab (感染症メタゲノム研究分野 中村研究室): “370A automated DNA sequencer” Giac83 / CC BY-SA 2.5 (cropped)
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