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32 labs · 0 student voices
Faculties at The University of Osaka ›
Toshio Kodama, Professor
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The Kodama Lab in the Department of Molecular Bacteriology studies the molecular mechanisms by which enteric bacterial pathogens exert pathogenicity. The lab also works to clarify the evolutionary processes that explain why particular bacterial strains cause global epidemics. Because of the AMR (antimicrobial resistance) problem, infection control that relies on antimicrobials alone is reaching its limits. By understanding these mechanisms, the lab aims to create concepts and methods that lead to new infection control strategies that do not depend on antimicrobials. The department belongs to the Division of Infection Mechanisms at the Research Institute for Microbial Diseases.
Tokiko Watanabe, Professor
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The Watanabe Lab in the Department of Molecular Virology studies viruses that cause zoonotic diseases, such as influenza virus and SARS-CoV-2. The lab investigates the mechanisms by which viruses are transmitted from animals to humans and how they cause disease. It also carries out research related to vaccine development and research on the epidemic status of viruses in wild animals in Africa and South America. The lab aims to apply its findings to infectious disease control in Japan and abroad.
Masahiro Yamamoto, Professor
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The Yamamoto Lab in the Department of Infection Pathogenesis studies, at the molecular level, the battle between pathogenic protozoan parasites or cancer and the host immunity that tries to eliminate them. From the viewpoint of host immunity, pathogens and cancer are alike in being foreign entities to be removed, and the lab believes that anti-pathogen immunity and anti-tumor immunity are remarkably similar. Using Toxoplasma gondii as a model, the lab uses genetically modified mice and parasites to investigate both the parasite side and the host side. The lab belongs to the Research Institute for Microbial Diseases and also serves as the Immunoparasitology laboratory of the Immunology Frontier Research Center (IFReC).
Kosuke Fujimoto, Professor
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The Fujimoto Lab aims to understand the human microbiome in fine detail and to elucidate how various diseases, including immune diseases, develop. Metagenomic analysis with next-generation sequencers is advancing, and it is becoming clear, one finding after another, that human diseases are closely linked to symbiotic pathogenic bacteria (pathobionts). The lab also puts effort into training researchers versed in both experimental (wet) and computational (dry) approaches. Going beyond the boundary between basic and clinical research, the lab pursues its work from both immunology and microbiology.
Sho Yamasaki, Professor
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The Yamasaki Lab studies immune receptors, which, within the immune system that protects the body, detect the invasion of foreign pathogens and abnormalities in the body. The lab has identified members of the lectin receptor family that recognize pathogens and damaged self components, and was the first to discover a group of receptors that recognize components of Mycobacterium tuberculosis. It also studies how T cells are selected in the thymus and how T cells respond to SARS-CoV-2.
Shizuo Akira, Project Professor
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The Akira Lab focuses its research on innate immunity. Innate immunity is a defense mechanism of the body that is activated at the earliest stage when pathogenic microorganisms invade, and that acts in triggering inflammatory responses and in establishing adaptive immunity. The lab has studied how pathogens are recognized by receptors such as Toll-like receptors (TLRs), as well as the intracellular signaling pathways involved. It now focuses on immune regulation through mRNA stability, aiming to clarify immunometabolism and the causes of various immune diseases and to establish new therapies.
Hisashi Arase, Professor
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The Immunochemistry Lab studies why the immune system, which evolved to protect the body from infection, can malfunction and cause abnormalities such as autoimmune diseases. The lab focuses on molecules that regulate the function of immune cells and examines how these molecules interact with the body's own molecules and with pathogens. It uses approaches such as genetically modified mice, single-cell analysis, and RNA-seq. The lab aims to uncover the causes behind questions such as why some people develop autoimmune diseases or cancer, and why some people become severely ill from infections.
Yoshiko Murakami, Project Professor
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The Glycan Immunology Lab studies how GPI-anchored proteins on the cell surface are made and what they do. GPI-anchored proteins are proteins attached to the cell membrane by the glycolipid GPI, and they include enzymes, receptors, and adhesion molecules. If GPI is not made in the correct structure and in the necessary amount, a disease called GPI deficiency results, so the lab aims to clarify its pathology and apply this to diagnosis and treatment.
Tetsuya Tetsuya, Professor
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The Immunometabolism Lab studies metabolism and immune cells in the body, where multiple organs work in coordination. The lab examines the role that metabolic signals play inside immune cells, and how immune cells affect whole-body metabolism. It also studies the roles that metabolic signals play in various types of cells. The lab belongs to the Department of Host Defense at the Research Institute for Microbial Diseases.
Eiji Hara, Professor
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The Hara Lab, in the Division of Molecular Biology, studies the relationship between aging and cancer, focusing on the phenomenon of cellular senescence. Cellular senescence is one of the safeguards by which cells stop proliferating when they detect abnormalities, and it acts to suppress cancer. On the other hand, the lab considers that senescent cells accumulating in the body with aging and obesity are one cause of the onset of various inflammatory diseases, including cancer. The lab aims to clarify how cellular senescence occurs and what it does, and to develop methods to control it.
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