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Horii Lab
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The lab develops a practical vaccine against falciparum malaria.
AboutAbout the lab
Bringing a malaria-preventing vaccine into practical use
The Malaria Vaccine Development Group (Horii Lab) is developing a highly effective vaccine against falciparum malaria for practical use.
At the same time, the lab analyzes the molecular mechanisms of the antigen genes that underpin the vaccine, aiming to apply its findings in vaccine development.
Falciparum malaria infects many people worldwide and causes many deaths, and the spread of drug-resistant strains is also a problem.
The lab belongs to the Research Center for Intractable Infectious Diseases and conducts its research as the Endowed Department for Malaria Vaccine Development.
Key terms
- Antigen
- A molecule that the immune system recognizes as a target. Vaccines aim to build immunity against it
- Genetic polymorphism
- Variation in the type of the same gene from strain to strain. Some parasites carry an antigen type that vaccine-induced immunity does not respond to
- Immune tolerance
- A state in which the immune system becomes less responsive to an antigen it has encountered repeatedly through infection
ResearchResearch themes
This lab is developing a highly effective vaccine against falciparum malaria for practical use. At the same time, it analyzes the molecular mechanisms of the antigen genes that underpin the vaccine, and aims to apply its findings in vaccine development.
*Illustrative imageVaccine Development Targeting SERA5
Focusing on the SERA5 antigen of Plasmodium falciparum, which shows almost no genetic polymorphism, the lab is developing the NPC-SE36 vaccine based on the recombinant SE36 protein. A clinical trial in young children in Burkina Faso confirmed its safety and immune response, and a new vaccine with a CpG adjuvant has also shown protective efficacy.
*Illustrative imageParasite Survival Strategies and the Role of SE36
The parasite has highly developed strategies for evading host immunity. The lab has shown that the SE36 protein covers the parasite surface and that host vitronectin binds to it, camouflaging the parasite with a host protein, and it is investigating how immune tolerance arises.
MembersFaculty
The members of the Horii Lab consist of the lab head (a Professor with a concurrent appointment) and a Project Professor.
- ProfessorTetsuya Tetsuya
- Project ProfessorToshihiro Horii
- Project ProfessorPALACPAC NIRIANNE MARIE QUERIJERO
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Plasmodium falciparum smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Vaccine Development Targeting SERA5: “Vaccination of a child” David Mark / CC0 (cropped)
- Parasite Survival Strategies and the Role of SE36: “Blood Cells (red) infected with malaria parasites (blue) with the small bumps on the infected cell show how the parasite remodels its host cell by forming protrusions called 'knobs' on the surface (2)” NIAID / CC BY 2.0 (cropped)
- Related lab (Kobayashi Lab): “Multiple rotavirus particles” Dr Graham Beards / CC BY 3.0 (cropped)
- Related lab (Tetsuya Lab): “TCBS agar plate of Vibrio Cholerae and vibrio parahaemolyticus” Chainwit. / CC BY-SA 4.0 (cropped)
- Related lab (Matsura Lab): “Hepatitis C” NIH Image Gallery / CC BY 2.0 (cropped)
- Related lab (Vaccine Creation Group Yoshioka Lab): “Vero Cell COVID-19 vaccine vial, cotton swab and syringe” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
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