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18 labs · 0 student voices
Faculties at The University of Osaka ›
Mitsuhiro Arisawa, Professor
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The lab develops new organic reactions and reagents and, as applications of them, studies the synthesis of biologically active natural products and their derivatives. The lab predicts properties and reactivity from molecular structure, pursues a single reaction in depth, and discovers new reactions. The reactions it discovers are applied to drug discovery research, with the aim of creating new compounds that surpass those found in nature. The lab also aims to train experts in synthetic organic chemistry through its research.
Satoshi Obika, Professor
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The lab conducts research grounded in nucleic acid chemistry, with the aim of making nucleic acids useful as drugs. Within the lab, there is a chemistry-based group and a biology-based group. The chemistry group works on chemically modifying nucleic acids using organic chemistry to enhance their usefulness as pharmaceuticals. The biology group aims to treat diseases by controlling the function of disease-related RNA.
Tsuyoshi Inoe, Professor
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The Biological Structure and Function Analysis Lab (Inoe Lab) studies the three-dimensional structures of disease-related proteins and applies them to drug development. Mainly using X-ray crystallography, the lab investigates how proteins work at the atomic level. The lab has also developed its own technology for finding proteins involved in disease. By combining its work with other fields such as polymer chemistry, the lab is also developing techniques to accelerate cryo-electron microscopy and antibody-based imaging technologies.
Kaori Fukuzawa, Professor
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The Quantum Life Informatics and Pharmaceutical Sciences Lab uses quantum chemical calculations to study the dynamics of biopolymers such as proteins, nucleic acids, and lipids at the atomic and molecular level. The lab applies the results to elucidating life science phenomena and designing drug molecules. By building a data infrastructure using the supercomputer Fugaku and applying artificial intelligence (AI), the lab aims to achieve the digital transformation (DX) of life science research based on quantum chemistry. The lab also works on analyzing the efficacy and side effects of drugs, epidemiological studies, and software development.
Masayoshi Arai, Professor
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The Natural Product Drug Discovery Lab searches for compounds that could become the basis of drugs from marine organisms such as sponges and from marine-derived microorganisms. The lab investigates how the compounds it finds act in the body, and also aims to develop them into drug candidate compounds through chemical synthesis. The lab is divided into an exploration group and a synthesis group, and pursues drug discovery research from the perspectives of both chemistry and biology. Students join one of the two groups according to their interests and conduct research there.
Takumi Ueda, Professor
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The Quantitative Biophysical Chemistry Lab studies the dynamic 3D structures of drug-target proteins that are directly linked to their activity. By integrating these findings with insights from methods in other fields, the lab aims to understand life phenomena as a whole and to accelerate drug discovery. The lab uses methods such as NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy. The lab is a division of the Graduate School of Pharmaceutical Sciences at The University of Osaka, and was previously named the Polymer Chemistry division.
Yoshinari Sawama, Professor
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The Functional Molecule Manufacturing Chemistry Lab builds on organic synthetic chemistry to research drug discovery using deuterium. The lab is pioneering a unique field, "deuterium science and deuterium drug discovery," which combines diversification through molecular structure with functionalization and refinement through deuterium. The lab also develops a wide range of catalytic organic synthesis methods, and is interested in developing green reactions that place no burden on the environment. The lab's website also introduces it under the name "Sawama Lab."
Hiroyuki Mizuguchi, Professor
0 student voices
The Molecular Biology Lab (Life Pharmaceutical Sciences Area) develops technologies for introducing genes into cells to control their function, and conducts molecular biology research using those technologies. The lab also creates hepatocytes and intestinal epithelial cells from stem cells such as human iPS cells, and uses them in drug discovery research. The lab's website also introduces it under the name "Mizuguchi Lab."
Tatsuya Saitoh, Professor
0 student voices
The Biological Response Regulation Lab (Prof. Saitoh's lab) studies the immune response, the biological response induced against foreign substances. While the immune response protects the body, when it is mistakenly directed against the body's own components or nutrients, it leads to autoimmune diseases and lifestyle-related diseases. The lab focuses in particular on innate immunity, investigating the immune mechanisms that prevent infections and cancer as well as the aberrant immune responses involved in the onset of disease. The lab also aims to develop therapeutic drugs that control the immune response.
Soichiro Fukada, Professor
0 student voices
The Regenerative Adaptation Lab studies the regenerative and hypertrophic capacities of skeletal muscle at the molecular level, aiming for discoveries that form the foundation for developing treatments for muscle diseases. The lab investigates how muscle satellite cells, the stem cells of skeletal muscle, are kept in a quiescent state, and how muscle hypertrophy and muscle regeneration occur. In addition to muscle diseases such as muscular dystrophy, the lab is interested in sarcopenia and cancer cachexia, where muscle atrophy is a problem.
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