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Ryuichiro Abe, Project Associate Professor
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The Pathogenic Bacteria Research Group (Abe Lab) analyzes the interrelationships among pathogenic bacteria, the host immunity that acts against them, and antimicrobial drugs. Its goal is to contribute to proposing better diagnostic methods and treatment guidelines. The lab studies the humoral bactericidal factors that act when bacteria enter the bloodstream, and the individual differences among pathogens. The lab is also jointly carrying out research that uses genome analysis results of carbapenem-resistant bacteria collected in Thailand.
Tetsuya Tetsuya, Professor
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The Bacterial Infection Division studies enteric infections and emerging and re-emerging infectious diseases that occur in Thailand through pathogen detection and epidemiological investigation. It is a division of the Japan–Thailand Research Collaboration Center on Emerging and Re-emerging Infections, and works with the Department of Medical Sciences of the Ministry of Public Health of the Kingdom of Thailand and the Division of Epidemiology of the Ministry's Department of Disease Control. Targeting patients with severe diarrheal diseases, including cholera, the division is working on early detection of the causative pathogens and on developing testing methods and preventive measures. It aims for its research results to be useful not only within Thailand but also for infectious disease control in neighboring Asian countries and Japan.
Takeshi Kobayashi, Professor (Concurrent)
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The lab studies viral intestinal infections and mosquito-borne infections that recur in Asian countries, including Thailand and Japan. As a division of the Japan-Thailand Joint Research Center for Infectious Diseases, the lab carries out its research together with researchers at the Department of Medical Sciences, Ministry of Public Health of the Kingdom of Thailand. Among mosquito-borne viruses, the lab focuses on antibody-dependent enhancement (ADE) of dengue virus infection. For intestinal infections, the lab studies norovirus, a cause of acute gastroenteritis, aiming to track changes in circulating strains and to clarify its life cycle.
Tetsuya Tetsuya, Professor
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As a division of the Japan-Thailand Joint Research Center for Infectious Diseases, the lab studies resistant bacteria that antibiotics cannot kill. Its central focus is carbapenem-resistant Enterobacteriaceae (CRE), which are resistant to carbapenem antibiotics, regarded as last-resort drugs for intractable infections. With the cooperation of core hospitals in Thailand and Myanmar, the lab collects clinical isolates of CRE and sequences their genomes. Using the resulting information, the lab aims to clarify how CRE acquire drug resistance genes and how they spread.
Takeshi Kobayashi, Center Director and Professor
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The Osaka-Mahidol Infectious Diseases Center conducts research toward developing point-of-care diagnostics for mosquito-borne viral diseases. Dengue fever and chikungunya fever are mosquito-borne viral infections that are epidemic mainly in tropical and subtropical regions, including the Kingdom of Thailand. Analyses of clinical specimens are carried out jointly with the Faculty of Tropical Medicine, Mahidol University, and research has begun to clarify the relationship between viruses and the factors that make disease severe. Through this joint research, the center also puts effort into training infectious disease researchers at the Faculty of Tropical Medicine, Mahidol University, and in Japan.
Yasuo Yoshioka, Project Professor
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The Vaccine Creation Group Yoshioka Lab researches the development of new vaccines against infectious diseases. Based on drug delivery science, safety science and toxicology, and protein engineering, the lab aims to achieve both strong vaccine efficacy and a level of safety and reassurance that allows people of all ages and genders to be vaccinated. Currently, the lab works on mRNA vaccines with reduced adverse reactions, intranasal vaccines, and antigen design based on structural vaccinology, and has also begun work on mRNA vaccines against cancer. In collaboration with the Research Foundation for Microbial Diseases of Osaka University (BIKEN), a leading company in vaccine development, the lab aims to create "the vaccines of 10 years from now."
Shinya Okamura, Project Assistant Professor
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The Virus Vaccine Group conducts virus research targeting infectious diseases for which no vaccines have been developed so far. Its targets include infectious diseases caused by pathogens that cannot be controlled by humoral immunity alone or that cannot be cultured, and diseases for which there is no animal model, making it difficult to evaluate efficacy. The goal is to develop a "world-first vaccine from Japan." The group is part of the BIKEN Next-Generation Vaccine Collaborative Research Institute, and through collaboration with the BIKEN Foundation, it pursues both basic and applied research.
Tadahiko Murata, Professor
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The RSSS Lab (Murata Lab) researches real-scale social simulation technology, which runs a virtual real society including humans on a computer. Using a digital twin of real society built in cyberspace, the lab simulates how individuals make decisions, such as in their movement and purchasing behavior. The synthetic population data used in the simulations are created from statistics. In addition to social simulation, the lab is also researching data generation in the field of drug discovery.
Yasushi Sakurai, Professor
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The Sakurai-Matsubara Lab researches technology that uses large-scale data to analyze the time evolution of natural and social phenomena in real time and optimize social activities. Targeting time series data such as IoT big data, the lab analyzes how various phenomena and activities change over time, working on discovering important patterns and predicting future events. The lab conducts joint research with companies toward practical application and also works on transferring its technology to industry. The lab belongs to the Institute of Scientific and Industrial Research at Osaka University and serves as a cooperating chair of the Graduate School of Information Science and Technology. Lab assignment is open to graduate students and third- and fourth-year undergraduates.
Susumu Date, Professor
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The Date Lab researches computing infrastructure and data infrastructure centered on supercomputing, as well as the applications built on them. The lab advances its research and development by drawing on its experience building and operating the D3 Center's supercomputing system, large-scale visualization system, and data infrastructure. It is a lab that studies the infrastructure needed for large-scale computation, such as AI development and numerical simulation. As a cooperating chair of the Graduate School of Information Science and Technology and the School of Engineering, the lab also works to develop people who will lead and pioneer this field.
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