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Takakura Lab
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The lab explores cancer therapy and regenerative medicine through the study of blood vessel formation.
AboutAbout the lab
How tissues are built and how they are destroyed.
The Takakura Lab, in the Division of Signal Transduction, studies how blood vessels form in order to apply the findings to cancer treatment and regenerative medicine.
In tissues such as the brain and intestine, tissue-specific stem cells differentiate into the necessary cells to form organs, and blood vessels create the environment that serves as their foundation.
The lab has shown that cancer stem cells proliferate by using the environment (niche) created by blood vessels, and is working to develop therapies aimed at a definitive cure for cancer.
The lab also accepts people from different fields such as engineering, and encourages interested people to visit the lab at least once.
Key terms
- Cancer stem cells
- Cells within a tumor that have the properties of stem cells. They exist near blood vessels and proliferate using the vascular environment.
- Niche
- The surrounding microenvironment that is important for tissue stem cells to be maintained and to proliferate. Blood vessels provide this environment.
- Vascular endothelial stem cells
- Stem cells that differentiate into normal blood vessels in vivo and are involved in keeping blood vessels maintained over the long term.
NewsLab news
An Assistant Professor received the Excellent Presentation Award at the 18th Annual Meeting of the Japanese Society of Immunotherapy for Hematologic Diseases
An Assistant Professor received the Young Investigator Award at the 50th Annual Meeting of the Japanese Society of Myeloma
Paper published in Inflammation and Regeneration
ResearchResearch themes
Tissues such as the brain and intestine form when appropriate cells differentiate from stem cells within the tissue environment. Focusing on blood vessels, which create the basis of this environment, the lab clarifies the molecular mechanisms of blood vessel formation and conducts research to apply the results to cancer treatment and regenerative medicine.
*Illustrative imageHow blood vessels form
Focusing on factors important for angiogenesis and vascular maturation and on the molecular mechanisms that create vascular patterns, the lab seeks to clarify the whole picture of how the structure and network of blood vessels are formed.
*Illustrative imageThe niche created by blood vessels and cancer stem cells
The lab has shown that cancer stem cells exist near blood vessels and proliferate by using the niche that the vessels create. Drawing on knowledge of blood vessel formation, it is working to develop therapies for a definitive cure for cancer.
*Illustrative imageRegenerative medicine using vascular endothelial stem cells
The lab has identified vascular endothelial stem cells, which differentiate into normal blood vessels in vivo and are involved in the long-term maintenance of blood vessels. It is conducting research toward the development and practical application of therapies using these cells.
MembersFaculty
The members of the Takakura Lab consist of faculty, Project Assistant Professors, project researchers, invited faculty and invited researchers, graduate students, and assistants.As of 2026
- ProfessorNobuyuki Takakura
- Assistant ProfessorFumitaka Muramatsu
- Assistant ProfessorWeizhen Jia
- Assistant ProfessorKensuke Hachiya
- Project Assistant ProfessorZeynep BAL
- Project Assistant ProfessorFitriana Nur Rahmawati
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image 3” Erin Rod / CC BY 4.0 (cropped)
- How blood vessels form: “Formation of the new blood vessels” Piotr Cywoniuk, Foundation of Research and Science Development, Poland Fundacja Badań i Rozwoju Nauki / CC BY 4.0 (cropped)
- The niche created by blood vessels and cancer stem cells: “Tumor Cells” Jlabanimation / CC BY-SA 4.0 (cropped)
- Regenerative medicine using vascular endothelial stem cells: “Regenerative medicine” Andrewrgross / CC BY-SA 4.0 (cropped)
- Related lab (Kotani Lab): “Epstein-Barr Virus (EBV) Particles” NIAID / CC BY 2.0 (cropped)
- Related lab (Kamimoto Lab): “Beckman Coulter CEQ 8800” Herodotptlomeu / CC BY-SA 4.0 (cropped)
- Related lab (Yamamoto Lab): “T. gondii tachyzoites” Persian Microbiologist / CC BY-SA 4.0 (cropped)
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