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Immunometabolism Lab
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A lab at the Research Institute for Microbial Diseases that explores the relationship between immune cells and whole-body metabolism.
AboutAbout the lab
Exploring the link between metabolism and immunity
The Immunometabolism Lab studies metabolism and immune cells in the body, where multiple organs work in coordination.
The lab examines the role that metabolic signals play inside immune cells, and how immune cells affect whole-body metabolism.
It also studies the roles that metabolic signals play in various types of cells.
The lab belongs to the Department of Host Defense at the Research Institute for Microbial Diseases.
Key terms
- Macrophage
- A type of immune cell. It clears dead cells, repairs tissue, phagocytoses pathogenic microorganisms, and causes inflammation.
- mTORC1
- A complex that is activated by gathering information about nutrients and drives the signals for cell proliferation and protein synthesis all at once.
- Ragulator
- A complex of five components that includes p18 (Lamtor1). It serves as a scaffold for the activation of mTORC1 by amino acids.
ResearchResearch themes
The body works through the coordinated action of multiple organs, and during an infection, the organs cooperate with the immune system at the center to eliminate pathogens. The lab focuses on metabolism and immune cells, and investigates the role of metabolic signals in immune cells and the effects of immune cells on whole-body metabolism.
*Illustrative imageExploring New Roles of Macrophages
Macrophages clear dead cells, repair tissue, and phagocytose pathogenic microorganisms. They have also been suggested to promote disease in conditions such as diabetes, organ fibrosis, and cancer progression, and the lab aims to uncover their unknown functions.
*Illustrative imageExploring Metabolic Signaling at the Lysosomal Membrane
Starting from p18 (Lamtor1), which was discovered at the Research Institute for Microbial Diseases, the lab studies metabolic signaling centered on the lysosomal membrane. It has shown that Ragulator is essential as a scaffold when mTORC1 phosphorylates TFEB.
MembersFaculty
The members of the Immunometabolism Lab consist of a Professor and a Project Assistant Professor.
- ProfessorTetsuya Tetsuya
- Project Assistant ProfessorTetsuya Kimura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Macrophage (NIH BioArt 312)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Exploring New Roles of Macrophages: “Macrophage (NIH BioArt 309)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Exploring Metabolic Signaling at the Lysosomal Membrane: “Lysosomes (NIH BioArt 306)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Arase Lab): “Cytotoxic T cell-ja” Template drawing and caption text from "The Immune System", any modifcations made by myself, are released into the public domain.; tossh_eng for ja label. / CC BY-SA 3.0 (cropped)
- Related lab (Yamasaki Lab): “Macrophage (NIH BioArt 311)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Akira Lab): “Toll-Like Receptors (TLRs)” Varun Punnam / CC BY-SA 4.0 (cropped)
- Related lab (Glycan Immunology Lab): “CSIRO ScienceImage 354 Influenza Protein Attaching to Cell Membrane” Health Sciences and Nutrition, CSIRO / CC BY 3.0 (cropped)
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