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927 labs · 0 student voices
Mariko Okada, Professor
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The Cell Systems Lab studies the relationship between cellular networks and the control of cell fate, focusing on the amounts, interactions, and changes over time of molecules inside cells. Combining quantitative experiments, mathematical models, and omics data analysis, the lab investigates the mechanisms that determine cell fate in cancer, the immune system, and the brain. The starting question is how cells select and process the necessary information from among many genes. On the lab's website, it is introduced under the name "Okada Lab."
Satoshi Toda, Associate Professor
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The Cell Function Design Lab studies how cells build complex tissues and organs, and how functions of cell populations, such as maintaining homeostasis and regeneration, arise. By freely designing the rules of interaction between cells and examining the behavior of cell populations, the lab aims to understand how tissues form and to develop new tissue engineering technologies. Using the approach of synthetic biology, which artificially creates life functions seen in living organisms, the lab conducts research with cultured cells and molecular biology techniques. The lab also works on developing new therapies based on manipulating cell-cell interactions.
Sandhya P. Tiwari, Independent Associate Professor
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The Biomolecular Dynamics Modeling Lab develops computational methods for modeling biomolecules and for studying changes in molecular shape (conformational dynamics). Because experimental and structural data are growing rapidly, the lab believes that even more sophisticated methods are needed to understand how biomolecules work in a more realistic way. The lab combines bioinformatics and data analysis methods to carry out modeling and simulation using existing data. On the lab's website, it is introduced under the English name 'Laboratory for Biomolecular Modeling and Design (LBMAD).'
Genji Kurisu, Professor
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The Protein Data Bank Development Lab is part of the Center for Advanced Protein Data Science, affiliated with the Institute for Protein Research at Osaka University, and handles work related to maintaining life science databases such as PDBj. PDBj (Protein Data Bank Japan) is one of the organizations that operate the PDB, which collects three-dimensional structural information on molecules such as proteins, and the EMDB, which collects information on Coulomb potential maps obtained by electron microscopy. Under the wwPDB (worldwide Protein Data Bank), PDBj works with RCSB PDB and BMRB in the US and PDBe and EMDB in Europe to operate a single, unified PDB/EMDB for the world. In addition, the lab is active in the BMRBj, EMPIAR Japan site, BSMA, and XRDa groups.
Nobuaki Okumura, Associate Professor
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The Biomolecular Analysis Lab studies how proteins and peptides are degraded in the body and how that degradation is regulated. From the perspectives of biochemistry, molecular biology, cell biology, and neuroscience, the lab aims to clarify part of the mechanisms that maintain homeostasis in the body. Equipped with analytical instruments such as mass spectrometers and protein sequencers, and working with the cooperation of the Institute for Protein Research's technical division, the lab provides an environment for studying the structure and function of proteins. The lab handles contract analysis of the N-terminal amino acid sequences of proteins and peptides using a protein sequencer, at the request of users inside and outside the institute.
Toshio Kodama, Professor
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The Kodama Lab in the Department of Molecular Bacteriology studies the molecular mechanisms by which enteric bacterial pathogens exert pathogenicity. The lab also works to clarify the evolutionary processes that explain why particular bacterial strains cause global epidemics. Because of the AMR (antimicrobial resistance) problem, infection control that relies on antimicrobials alone is reaching its limits. By understanding these mechanisms, the lab aims to create concepts and methods that lead to new infection control strategies that do not depend on antimicrobials. The department belongs to the Division of Infection Mechanisms at the Research Institute for Microbial Diseases.
Tokiko Watanabe, Professor
0 student voices
The Watanabe Lab in the Department of Molecular Virology studies viruses that cause zoonotic diseases, such as influenza virus and SARS-CoV-2. The lab investigates the mechanisms by which viruses are transmitted from animals to humans and how they cause disease. It also carries out research related to vaccine development and research on the epidemic status of viruses in wild animals in Africa and South America. The lab aims to apply its findings to infectious disease control in Japan and abroad.
Masahiro Yamamoto, Professor
0 student voices
The Yamamoto Lab in the Department of Infection Pathogenesis studies, at the molecular level, the battle between pathogenic protozoan parasites or cancer and the host immunity that tries to eliminate them. From the viewpoint of host immunity, pathogens and cancer are alike in being foreign entities to be removed, and the lab believes that anti-pathogen immunity and anti-tumor immunity are remarkably similar. Using Toxoplasma gondii as a model, the lab uses genetically modified mice and parasites to investigate both the parasite side and the host side. The lab belongs to the Research Institute for Microbial Diseases and also serves as the Immunoparasitology laboratory of the Immunology Frontier Research Center (IFReC).
Kosuke Fujimoto, Professor
0 student voices
The Fujimoto Lab aims to understand the human microbiome in fine detail and to elucidate how various diseases, including immune diseases, develop. Metagenomic analysis with next-generation sequencers is advancing, and it is becoming clear, one finding after another, that human diseases are closely linked to symbiotic pathogenic bacteria (pathobionts). The lab also puts effort into training researchers versed in both experimental (wet) and computational (dry) approaches. Going beyond the boundary between basic and clinical research, the lab pursues its work from both immunology and microbiology.
Sho Yamasaki, Professor
0 student voices
The Yamasaki Lab studies immune receptors, which, within the immune system that protects the body, detect the invasion of foreign pathogens and abnormalities in the body. The lab has identified members of the lectin receptor family that recognize pathogens and damaged self components, and was the first to discover a group of receptors that recognize components of Mycobacterium tuberculosis. It also studies how T cells are selected in the thymus and how T cells respond to SARS-CoV-2.
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