Labs in The University of Osaka

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A lab that investigates the mechanisms of emerging viruses such as Lassa virus.

The Division of Infectious Disease Drug Discovery Science studies emerging viral infectious diseases as the Iwasaki Lab of the Research Institute for Microbial Diseases. It focuses in particular on Lassa virus, which has a high fatality rate and for which there are no established treatments or preventive methods. Using methods from virology, immunology, molecular biology, RNA biology, bioinformatics, and chemical biology, the lab aims to elucidate how viruses replicate and how they cause disease. Based on the findings, the lab also works on developing new diagnostic methods, treatments, and preventive methods.

#Lassa virus #Emerging viruses #Vaccines

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The lab searches for treatments for cardiovascular disease based on the structure and function of proteins.

The Department of Molecular Pharmacology searches for molecules that can serve as therapeutic targets and aims to create new treatments, with the goal of conquering cardiovascular disease. Using methods from biochemistry, pharmacology, genetics, molecular biology, structural biology, and computational chemistry, the lab investigates how target molecules function and how that function breaks down in disease. Its main research subjects are the respiratory chain enzymes of mitochondria and membrane proteins involved in inflammation of the heart muscle. The lab's website is presented under the name "Department of Molecular Pharmacology" at the Research Institute, National Cerebral and Cardiovascular Center.

#Mitochondria #Cytochrome c oxidase #Structure-based drug discovery

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The lab investigates the mechanisms of heart failure and aims to develop new treatments.

The Department of Heart Failure Pathophysiology and Control aims to clarify the pathophysiology of heart failure, find new therapeutic targets, and develop effective treatments. Heart failure has a high prevalence and a poor prognosis, so developing effective treatments is considered urgent. Focusing on cardiomyocyte death, autophagy, and sterile inflammation, the lab investigates molecular mechanisms mainly in mouse models of heart failure. The lab's website presents it under the name "Department of Heart Failure Pathophysiology and Control."

#Heart failure #Autophagy #Inflammation

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The lab develops vaccine materials based on the mechanisms of mucosal immunity.

The lab conducts basic immunology research focusing on the unique features of mucosal immunity, and applies the findings to the development of mucosal vaccines and immunotherapies. Inhaled and oral mucosal vaccines have been put into practical use for some infectious diseases, but extending them to other infectious diseases and allergies requires the development of vaccine materials. The lab's website is presented as the "Vaccine Materials Project" of the National Institutes of Biomedical Innovation, Health and Nutrition. Students of the Graduate School of Pharmaceutical Sciences at Osaka University also join the lab as affiliated graduate students.

#Mucosal immunity #Vaccine materials #Gut environment

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The lab designs next-generation antibody therapeutics based on how antibodies bind to their targets.

The Antibody Therapeutics Design Lab takes the binding mode, meaning where and how an antibody binds to its target, as the object of analysis and design, and conducts research aimed at creating next-generation antibody therapeutics. By combining its proprietary "epitope-homogenized antibody panel" technology with AI-based structural modeling, the lab is shifting from empirical exploration to rational design. Focusing on intractable diseases such as cancer, immune disorders, and infectious diseases, the lab's main drug discovery targets are membrane proteins such as GPCRs and immune checkpoint molecules. The lab's website is the "Antibody Design Project" page of the National Institutes of Biomedical Innovation, Health and Nutrition, which lists related links for the Osaka University Cooperative Graduate School (Biomedical Innovation Science chair).

#Antibody therapeutics #Binding modes #AI structural modeling

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核輸送動力学分野 (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.

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The lab carries out everything from artificial nucleic acid synthesis to screening, aiming to develop nucleic acid therapeutics.

The Nucleic Acid Therapeutics Design Lab studies the development of nucleic acid therapeutics that use artificially made nucleic acids. The lab works on synthesizing artificial nucleic acids to be introduced into nucleic acid therapeutics such as antisense nucleic acids and aptamers, and on developing screening methods to efficiently select promising sequences. Because nucleic acid therapeutics can target almost any molecule in the body, including DNA, RNA, and proteins, they are expected to lead to the development of highly effective drugs for intractable diseases that are difficult to treat with existing methods. The lab's website presents it as the "Artificial Nucleic Acid Screening Project" of the National Institutes of Biomedical Innovation, Health and Nutrition, and students from the Graduate School of Pharmaceutical Sciences at Osaka University join as cooperative graduate students.

#Nucleic acid therapeutics #Artificial nucleic acids #Aptamers

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The lab discovers drug targets for antibody therapeutics and develops the underlying technologies.

The Drug Target Discovery Lab studies foundational technologies for developing biopharmaceuticals such as antibody therapeutics. In particular, the lab works on discovering molecules that can serve as targets for antibody therapeutics and on developing new types of antibody derivatives based on antibodies. The lab operates as the Biopharmaceutical Discovery Project of the National Institutes of Biomedical Innovation, Health and Nutrition, and accepts graduate students as a field of the cooperative graduate school of the Graduate School of Pharmaceutical Sciences at Osaka University. The lab's website introduces it under the name "Biopharmaceutical Discovery Project." The research content is based on the website's description from around 2022.

#Antibody therapeutics #Drug target discovery #Phage display

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A lab that uses computers to tackle drug discovery and the mechanisms of disease.

The Mizuguchi Lab conducts research and technology development that use computers to make drug development more efficient, and works to elucidate the mechanisms of disease. The lab does not conduct any experiments using animals or microorganisms; its research is carried out entirely with computers. This field is called bioinformatics, and the lab aims to contribute to drug development in collaboration with researchers who conduct experiments. On the website, the lab is listed under the name "Mizuguchi Lab" (Computational Biology Lab, Institute for Protein Research).

#Bioinformatics #Data integration #Drug discovery

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A lab that uses primates in medical research, aiming to control diseases.

The Primate Medical Science Lab is a cooperative graduate school field of the Graduate School of Pharmaceutical Sciences, Osaka University, and is based at the National Institutes of Biomedical Innovation, Health and Nutrition. The institute's Research Center for Primate Medical Science conducts medical research using primates across a broad range, from basic research to putting the results to practical use in medicine. With disease control as its ultimate goal, the center also works on creating disease models and on vaccine development. The center has labs for infectious diseases, genetic diseases, reproduction, and genome analysis.

#Primates #Disease models #Infectious diseases