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Cardiovascular Therapeutics Development Lab
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The lab investigates the mechanisms of heart failure and aims to develop new treatments.
AboutAbout the lab
Creating new treatments from the mechanisms of heart failure
The Department of Heart Failure Pathophysiology and Control aims to clarify the pathophysiology of heart failure, find new therapeutic targets, and develop effective treatments.
Heart failure has a high prevalence and a poor prognosis, so developing effective treatments is considered urgent.
Focusing on cardiomyocyte death, autophagy, and sterile inflammation, the lab investigates molecular mechanisms mainly in mouse models of heart failure.
The lab's website presents it under the name "Department of Heart Failure Pathophysiology and Control."
Key terms
- Autophagy
- A mechanism by which cells break down their own components. It is considered essential for maintaining the condition of cardiomyocytes
- Sterile inflammation
- Inflammation not caused by infection (non-infectious inflammation). It is thought to play an important role in heart failure as well
- Mitophagy
- Autophagy that selectively degrades mitochondria, the organelles that produce energy
ResearchResearch themes
The lab aims to clarify the pathophysiology of heart failure, find new therapeutic targets, and lead to the development of effective treatments. It investigates molecular mechanisms such as cardiomyocyte death, autophagy, and sterile inflammation.
*Illustrative imageHow inflammation arises in the heart
The lab investigates the mechanisms of cardiac inflammation that originates in cardiomyocytes and cardiac fibroblasts. It works to clarify how inflammatory cytokines are produced and degraded.
*Illustrative imageMitophagy and metabolic abnormalities
The lab focuses on mitophagy, the selective degradation of mitochondria. It has identified Bcl-2-like protein 13, a receptor essential for initiating mitophagy, and is examining its role in vivo in heart failure.
*Illustrative imageIron metabolism in cardiomyocytes and heart failure
The lab investigates how the abnormal iron metabolism seen in heart failure patients contributes to the onset and progression of the disease. It has shown that pressure overload on the heart may promote heart failure through mechanisms such as an increase in free iron in the heart, and it aims to clarify the role of iron metabolism.
*Illustrative imageSearching for new therapeutic targets and drugs
The lab aims to develop therapeutics mainly using mouse models of heart failure. It is also attempting to identify therapeutic targets by high-throughput screening, using cardiomyocytes derived from iPS cells of patients with hereditary heart disease together with a library of drug molecules.
MembersFaculty
The members of the Department of Heart Failure Pathophysiology and Control consist of the department head, laboratory heads, senior researchers, research fellows, research assistants, dispatched trainees, research support staff, and visiting researchers.As of 2026
- DirectorShigemiki Omiya
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mammal heart model 01- FMVZ USP-03” Wagner Souza e Silva / CC BY-SA 4.0 (cropped)
- How inflammation arises in the heart: “Viral myocarditis (1)” BellRap / CC BY-SA 3.0 (cropped)
- Mitophagy and metabolic abnormalities: “Mitochondrial Fission and Fusion” Rtian96 / CC BY-SA 4.0 (cropped)
- Iron metabolism in cardiomyocytes and heart failure: “Cellular iron homeostasis” Neodop / CC BY-SA 4.0 (cropped)
- Searching for new therapeutic targets and drugs: “Cardiovascular system - Diastolic heart failure -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
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