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Drug Target Discovery Lab
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The lab discovers drug targets for antibody therapeutics and develops the underlying technologies.
AboutAbout the lab
Developing foundational technologies for next-generation biopharmaceuticals.
The Drug Target Discovery Lab studies foundational technologies for developing biopharmaceuticals such as antibody therapeutics.
In particular, the lab works on discovering molecules that can serve as targets for antibody therapeutics and on developing new types of antibody derivatives based on antibodies.
The lab operates as the Biopharmaceutical Discovery Project of the National Institutes of Biomedical Innovation, Health and Nutrition, and accepts graduate students as a field of the cooperative graduate school of the Graduate School of Pharmaceutical Sciences at Osaka University.
The lab's website introduces it under the name "Biopharmaceutical Discovery Project."
The research content is based on the website's description from around 2022.
Key terms
- Drug target
- A molecule that a drug acts on. For antibody therapeutics, membrane proteins on the cell membranes of diseased tissue are important.
- Epitope
- The part of an antigen to which an antibody binds. It correlates with the antigen's function and provides clues for making functional antibodies.
- ADC
- A conjugate of an antibody and a drug. It is being developed as a technology for delivering drugs to cancer.
ResearchResearch themes
The lab studies foundational technologies for developing highly effective biopharmaceuticals for diseases that are difficult to treat with existing drugs, such as intractable cancers. In particular, it is advancing the discovery of drug targets for antibody therapeutics and the development of new types of antibody derivatives based on antibodies.
*Illustrative imageTechnology for finding targets of antibody therapeutics
Using new labeling reagents, the lab attempts to identify drug targets for antibody drugs. It also uses "in vivo labeling technology," in which labeled compounds are perfused into model animals, keeping in mind the behavior of antibody therapeutics in the body after administration.
*Illustrative imageNew formats of antibody derivatives
Based on antibodies, the lab creates antibody derivatives with new formats. With ADCs, which are being developed as an active targeting technology for cancer, in mind, it is producing new antibody formats.
*Illustrative imageAntibody analysis focused on epitopes
The lab analyzes the epitopes bound by antibodies both statically and dynamically to draw out the potential of antibodies. This technology development, aimed at finding the optimal antibody for therapeutic development, is carried out jointly with the Antibody Design Project.
*Illustrative imageLibrary construction by phage display
Using phage display, the lab constructs libraries of protein variants and of proteins and peptides based on antibodies. From these libraries it selects functional molecules and searches for therapeutic candidates that target the tumor necrosis factor (TNF) superfamily.
MembersFaculty
The members of the Drug Target Discovery Lab are project leaders, project researchers, specially appointed researchers, technical assistants, research coordination specialists, and graduate students accepted as trainees.
- Visiting ProfessorHaruhiko Kamada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Monoclonal antibodies (3)” Linda Bartlett (Photographer) / Public domain (cropped)
- Technology for finding targets of antibody therapeutics: “Antibody-drug conjugate” Bioconjugator / CC BY-SA 4.0 (cropped)
- New formats of antibody derivatives: “Cetuximab” Oguenther at German Wikipedia / Public domain (cropped)
- Antibody analysis focused on epitopes: “Epitope-mapping illustration-6-copy” Kathryn Edmondson (as employee of Integral Molecular) / CC BY-SA 4.0 (cropped)
- Library construction by phage display: “Phage display” Thomas Shafee / CC BY 4.0 (cropped)
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