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Vaccine Materials Science Lab
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The lab develops vaccine materials based on the mechanisms of mucosal immunity.
AboutAbout the lab
From the uniqueness of mucosal immunity to vaccine development
The lab conducts basic immunology research focusing on the unique features of mucosal immunity, and applies the findings to the development of mucosal vaccines and immunotherapies.
Inhaled and oral mucosal vaccines have been put into practical use for some infectious diseases, but extending them to other infectious diseases and allergies requires the development of vaccine materials.
The lab's website is presented as the "Vaccine Materials Project" of the National Institutes of Biomedical Innovation, Health and Nutrition.
Students of the Graduate School of Pharmaceutical Sciences at Osaka University also join the lab as affiliated graduate students.
Key terms
- Vaccine materials
- Materials needed to put new vaccines into practical use, such as vaccine delivery systems and adjuvants
- Mucosal vaccine
- A vaccine that is inhaled or taken orally
- IgA-producing cells
- Immune cells that play a central role in host defense in mucosal tissues
- DDS
- Drug delivery system. A technology for delivering a drug to where it is needed
ResearchResearch themes
Based on the specificity of mucosal immunity and on immune regulation mediated by gut environmental factors, the lab develops vaccine materials such as vaccine delivery systems and adjuvants. It is advancing next-generation vaccines and diagnostics for various infectious diseases and for allergic and inflammatory diseases.
*Illustrative imageCreating materials effective for mucosal vaccines
Focusing on dietary components that modulate immunity, such as lipids, vitamins, and herbal medicine ingredients, the lab is applying their metabolites and structural analogs to vaccines. It has also clarified how bacteria that live symbiotically in gut-associated lymphoid tissue promote vaccine effects.
*Illustrative imageUnderstanding mucosal immunity and developing novel vaccines
The lab is developing mucosal vaccines that exploit the mechanisms by which IgA-producing cells, which are central to host defense at mucosal surfaces, are differentiated and induced. It also works on a safety evaluation system using an antibody library that can identify mast cells, and on applications to DDS (drug delivery systems).
MembersFaculty
The members of the lab consist of faculty, researchers, JSPS Research Fellows, project researchers, affiliated graduate students, research coordination specialists, technical assistants, administrative assistants, visiting researchers, collaborating researchers, and trainees.As of 2026
- Visiting ProfessorJun Kunisawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mucosal immunity” Faria, Ana M.C.; Reis, Bernardo S.; Mucida, Daniel / CC BY-SA 4.0 (cropped)
- Creating materials effective for mucosal vaccines: “B vitamin supplement tablets” Ragesoss / CC BY-SA 3.0 (cropped)
- Understanding mucosal immunity and developing novel vaccines: “Mucosal immunity March 18” Olgamatveeva / CC BY-SA 4.0 (cropped)
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