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Nucleic Acid Drug Design Lab
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The lab carries out everything from artificial nucleic acid synthesis to screening, aiming to develop nucleic acid therapeutics.

AboutAbout the lab
Creating artificial nucleic acids to produce nucleic acid therapeutics.
The Nucleic Acid Therapeutics Design Lab studies the development of nucleic acid therapeutics that use artificially made nucleic acids.
The lab works on synthesizing artificial nucleic acids to be introduced into nucleic acid therapeutics such as antisense nucleic acids and aptamers, and on developing screening methods to efficiently select promising sequences.
Because nucleic acid therapeutics can target almost any molecule in the body, including DNA, RNA, and proteins, they are expected to lead to the development of highly effective drugs for intractable diseases that are difficult to treat with existing methods.
The lab's website presents it as the "Artificial Nucleic Acid Screening Project" of the National Institutes of Biomedical Innovation, Health and Nutrition, and students from the Graduate School of Pharmaceutical Sciences at Osaka University join as cooperative graduate students.
Key terms
- Artificial nucleic acid
- A nucleic acid (XNA) made artificially using chemical technology. It is introduced into nucleic acid therapeutics.
- Antisense nucleic acid
- A nucleic acid therapeutic that acts in a sequence-specific manner on a target mRNA to regulate its translation into a disease-causing protein.
- Aptamer
- A nucleic acid therapeutic that binds in a structure-specific manner to a disease-causing protein and regulates its activity.
ResearchResearch themes
The lab synthesizes artificial nucleic acids to be introduced into nucleic acid therapeutics and develops screening methods to efficiently select active sequences. Handling everything from artificial nucleic acid synthesis to screening and development research, it aims to develop nucleic acid therapeutics for a wide range of diseases, including intractable rare diseases.
View More ↗MembersFaculty
The members of the Nucleic Acid Therapeutics Design Lab are project leaders, sub-project leaders, specially appointed researchers, technical assistants, administrative assistants, visiting researchers, cooperative graduate students, and trainees.
- Project LeaderYuya Kasahara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “RNA polymerase transcribing template strand DNA” Kep17 / CC BY-SA 4.0 (cropped)
- Synthesis and screening of artificial nucleic acids: “DNA vs PNA structure comparison” Kel.russell / CC0 (cropped)
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