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927 labs · 0 student voices
Cevayir Coban, Professor
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The Malaria Immunology lab studies the immune response to infection with malaria parasites. Malaria parasites infect both mammals and Anopheles mosquitoes, and have evolved a variety of strategies to evade the host immune system. Using mouse models of malaria and genetically modified mice lacking various genes, the lab applies imaging and immunological methods to investigate parasite-host interactions and disease pathology. The lab was established in 2010 at the Immunology Frontier Research Center (IFReC) at Osaka University, and in 2019 it moved its base to the Institute of Medical Science, the University of Tokyo, where it continues its research and education.
Masahiro Yamamoto, Professor
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The Immunoparasitology lab studies the mechanisms of the battle between pathogenic protozoan parasites or cancer and the immune system that protects the body. The lab places importance on investigating how infection is established and how immunity works, from the perspectives of both the parasite and the host. Based on the idea that immunity against protozoan parasites and immunity against cancer are strikingly similar, the lab works on both infection immunity and cancer immunity. On the lab's website, it is introduced as the "Yamamoto Lab" of the Division of Infection Pathogenesis at the Research Institute for Microbial Diseases.
Shigekazu Nagata, Professor
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The Biochemistry and Immunology lab studies a form of cell death called apoptosis and the mechanisms by which dead cells are cleared by phagocytes. Cells that have undergone apoptosis are taken up by phagocytes with their contents intact and then cleared, which is why apoptosis is also called "clean cell death." The lab has investigated the proteins and enzymes involved in clearing dead cells, using knockout mice as well. On the lab's website, it is introduced under the name "Shigekazu Nagata Lab."
Toshihide Yamashita, Professor
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The Molecular Neuroscience Lab conducts basic and translational research to overcome the lasting impairments that follow damage to the central nervous system, including the brain and spinal cord. In the brain and spinal cord, neurons function by forming networks with one another, and once these networks are damaged, recovery is extremely rare. The lab believes that if lost networks can be repaired, central nervous system disorders can be treated, and it aims to establish new nerve regeneration therapies. In addition, it seeks to take an integrated approach to the question of dynamics in the repair process of neural circuits. Note that the lab's approach described here is based on the professor's greeting page (written around 2018).
Sho Yamasaki, Professor
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The Yamasaki Lab, in the Division of Molecular Immunology at the Research Institute for Microbial Diseases, studies immune receptors, the part of the body's protective immune system that quickly detects the invasion of foreign invaders and abnormalities in the body. The lab has discovered members of the lectin receptor family that recognize pathogens and damaged self components, and it aims to apply this to methods for efficiently enhancing immunity and to treatments for diseases caused by excessive immune reactions. The lab also investigates the selection mechanisms that operate as T cells develop in the thymus, and the T cell response to SARS-CoV-2. Graduate students are accepted from the Graduate School of Medicine and the Graduate School of Frontier Biosciences.
Takashi Nagasawa, Professor
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The Stem Cell Biology and Developmental Immunology Lab studies the physiology and pathology of the microenvironment (niche) that maintains and regulates hematopoietic stem cells and immune cells in the bone marrow. Tissue stem cells are special cells that can give rise to various mature cells and divide repeatedly, and they are responsible for maintaining tissues and regenerating damaged ones. The lab discovered CAR cells, which form the hematopoietic stem cell niche in the bone marrow, and showed that CAR cells are also mesenchymal stem cells that give rise to osteoblasts and adipocytes. In the Graduate School of Medicine's list of departments, Prof. Nagasawa's department is also listed under the name "Stem Cell Biology."
Eiji Hara, Professor
0 student voices
The Aging Biology Lab studies the relationship between aging and cancer, focusing on the phenomenon of cellular senescence. The lab believes that the accumulation of senescent cells in the body with aging and obesity is one cause of inflammatory diseases, including cancer. It investigates how cellular senescence occurs and how it affects the body, with the aim of developing methods to control cellular senescence. On the lab's website, it is presented under the name "Hara Lab" as a lab of the Research Institute for Microbial Diseases.
Nobuyuki Takakura, Professor
0 student voices
The Signal Transduction Lab (Takakura Lab) studies how tissues and organs are formed, based on the functions of blood vessels and stem cells. It aims to clarify how blood vessels are formed and to apply the results to cancer treatment and regenerative medicine. The lab brings together graduate students and researchers with diverse backgrounds, such as medicine, pharmaceutical sciences, science, and engineering. It is a division of the Research Institute for Microbial Diseases, and is also listed in the faculty list of the Immunology Group at the Immunology Frontier Research Center.
Manabu Fujimoto, Professor
0 student voices
The Cutaneous Immunology Lab is part of the Department of Dermatology at Osaka University, and its main themes, led by Prof. Fujimoto, are connective tissue diseases and immune diseases, including systemic sclerosis and dermatomyositis. In a greeting from May 2019, Prof. Fujimoto stated the intention to elucidate the pathophysiology of these intractable diseases and to establish treatments, working at Osaka University, a center of immunology. In the same greeting, Prof. Fujimoto also stated that the mission of the Department of Dermatology at Osaka University is to be able to provide the best medical care for every skin disease. The lab's website covers the entire Department of Dermatology, and its research page lists the research of each professor.
Kazuyo Moro, Professor
0 student voices
Moro Lab studies the immune cells called group 2 innate lymphoid cells (ILC2), which it was the first in the world to report, in 2010. The lab approaches its research from multiple directions, from basic research on how ILC2 differentiate, are activated, and are suppressed, to drug discovery and development. The lab is located at both the Osaka University Graduate School of Medicine and RIKEN, and students can conduct research at either one. At the Immunology Frontier Research Center, the lab is listed as "Immunology and Allergy," while on the lab's own website it is listed as "Moro Lab."
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