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Biochemistry and Immunology Lab
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A lab that explores how cells die and how dead cells are cleared.
AboutAbout the lab
Unraveling cell death and its cleanup
The Biochemistry and Immunology lab studies a form of cell death called apoptosis and the mechanisms by which dead cells are cleared by phagocytes.
Cells that have undergone apoptosis are taken up by phagocytes with their contents intact and then cleared, which is why apoptosis is also called "clean cell death."
The lab has investigated the proteins and enzymes involved in clearing dead cells, using knockout mice as well.
On the lab's website, it is introduced under the name "Shigekazu Nagata Lab."
Key terms
- Apoptosis
- A form of cell death in which the cell is taken up by phagocytes with its contents intact and cleared.
- Macrophage
- A type of phagocyte that takes up and clears dead cells and other material.
- Phagocytosis
- The process by which phagocytes take up and clear dead cells and other material.
- Phosphatidylserine
- A molecule displayed on the surface of apoptotic cells that serves as an "eat me" signal.
NewsLab news
A paper by Project Professor Nagata and colleagues was published in Journal of Clinical Investigation
Project Assistant Professor Takaharu Sakuragi received the Japanese Biochemical Society Encouragement Award
A paper by Project Professor Nagata and colleagues was published in Journal of Biological Chemistry
A paper by Project Professor Nagata and colleagues was published in Proceedings of the Japan Academy, Series B
ResearchResearch themes
The lab studies the mechanisms by which the form of cell death called apoptosis occurs, and by which dead cells are cleared by phagocytes. It has investigated the recognition of the "eat me" signal that dead cells display on their surface and the action of enzymes that degrade DNA, including through the analysis of knockout mice.
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MembersFaculty
The members of the Biochemistry and Immunology lab consist of faculty, project researchers, joint researchers, special auditing students, laboratory assistants, and secretaries.As of 2026
- ProfessorShigekazu Nagata
- Project Associate ProfessorTakaharu Sakuragi
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “WBCs, apoptosis and echinocytosis in peripheral blood smear, May-Grünwald stain” Bondarev.gal / CC BY 4.0 (cropped)
- How dead cells are engulfed and cleared: “Macrophage (NIH BioArt 309)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Immunology and Allergy Lab): “T Lymphocyte known as a T cell - 2231” NIAID / CC BY 2.0 (cropped)
- Related lab (Signal Transduction Lab): “Bovine Pulmonary Artery Endothelial Cells Fluorescent Image” Erin Rod / CC BY 4.0 (cropped)
- Related lab (Human Single Cell Immunology Lab): “Lymph Node (NIH BioArt 304)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
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