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Aging Biology Lab
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The lab explores the link between aging and carcinogenesis by studying the mechanisms of cellular senescence.
AboutAbout the lab
Exploring the link between aging and carcinogenesis.
The Aging Biology Lab studies the relationship between aging and cancer, focusing on the phenomenon of cellular senescence.
The lab believes that the accumulation of senescent cells in the body with aging and obesity is one cause of inflammatory diseases, including cancer.
It investigates how cellular senescence occurs and how it affects the body, with the aim of developing methods to control cellular senescence.
On the lab's website, it is presented under the name "Hara Lab" as a lab of the Research Institute for Microbial Diseases.
Key terms
- Cellular senescence
- One of the safety mechanisms by which cells that sense an abnormality stop proliferating. It acts to suppress abnormal cell proliferation.
- SASP
- A phenomenon in which senescent cells secrete large amounts of various factors, such as inflammatory cytokines and growth factors.
- Gut microbiota
- The community of diverse microorganisms, mainly bacteria, that proliferate in the intestine.
NewsLab news
Published in EMBO Reports on problems with detecting and eliminating senescent cells in p16-3MR mice
Published in EMBO Reports a re-examination of the effects of senolytic drugs
ResearchResearch themes
The lab aims to clarify the mechanisms by which cellular senescence occurs and its effects on the body, and to develop methods to control cellular senescence. It is becoming clear that cells that have undergone senescence secrete large amounts of inflammatory cytokines and other factors through a phenomenon called SASP (senescence-associated secretory phenotype), which causes inflammation and promotes carcinogenesis.
View More ↗MembersFaculty
Members of the Aging Biology Lab consist of faculty, joint researchers from companies, doctoral and master's students, technical staff, technical assistants, and a secretary.As of 2026
- ProfessorEiji Hara
- LecturerMasahiro Wakita
- Assistant ProfessorKen Uemura
- Assistant ProfessorNoriko Shinjo
- Project Assistant ProfessorYumi Katayama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “T Cell Senescence (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Malaria Immunology Lab): “Malaria falciparum ring forms” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (Microbiology and Immunology Lab): “Inflammed mucous layer of the intestinal villi depicting Celiac disease” www.scientificanimations.com / CC BY-SA 4.0 (cropped)
- Related lab (Cellular Immunotherapy Lab): “Architektur eines chimären Antigenrezeptors (CAR)” Michels, A., Hartmann, J. & Buchholz, C.J. / CC BY 4.0 (cropped)
- Related lab (Mucosal Immunology Lab): “Culture Plates” Katherine Stember / CC BY 4.0 (cropped)
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