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Cutaneous Immunology Lab
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The lab explores the mechanisms of intractable diseases involving connective tissue diseases and skin immunity.
AboutAbout the lab
Aiming to elucidate the pathophysiology of intractable diseases and establish treatments.
The Cutaneous Immunology Lab is part of the Department of Dermatology at Osaka University, and its main themes, led by Prof. Fujimoto, are connective tissue diseases and immune diseases, including systemic sclerosis and dermatomyositis.
In a greeting from May 2019, Prof. Fujimoto stated the intention to elucidate the pathophysiology of these intractable diseases and to establish treatments, working at Osaka University, a center of immunology.
In the same greeting, Prof. Fujimoto also stated that the mission of the Department of Dermatology at Osaka University is to be able to provide the best medical care for every skin disease.
The lab's website covers the entire Department of Dermatology, and its research page lists the research of each professor.
Key terms
- Connective tissue diseases
- Intractable diseases that include systemic sclerosis and dermatomyositis. B cells, T cells, and others are thought to be involved in their pathophysiology.
- Autoantibodies
- Antibodies that bind to components of one's own body. In dermatomyositis, classification into subsets (subtypes) according to the type of autoantibody is being studied.
- Regulatory B cells
- A newly identified B cell subset that suppresses immune responses. Also called Bregs.
- Resident memory T cells
- A fraction of T cells that, once they have migrated into a tissue, do not recirculate and remain there.
NewsLab news
View More ↗ResearchResearch themes
According to Prof. Fujimoto's greeting from May 2019, the aim is to elucidate the pathophysiology of connective tissue diseases and immune diseases, including systemic sclerosis and dermatomyositis, and to establish treatments. The department's research page (with representative papers up to around 2020) introduces basic and clinical research on connective tissue diseases, as well as research on B cells and T cells, organized by individual professors.
*Illustrative imagePathophysiology of connective tissue diseases and autoantibodies
The lab conducts basic and clinical research investigating the pathogenic mechanisms of systemic sclerosis, dermatomyositis, and related diseases. For dermatomyositis, it has published pioneering results on subset classification based on specific autoantibodies.
*Illustrative imageB cells and skin diseases
Focusing on CD19 and CD22, signal transduction molecules on the B cell surface membrane, the lab studies the mechanisms of signaling and their relationship to autoimmune diseases. It also investigates the role that regulatory B cells (Bregs), which suppress immune responses, play in immune-mediated skin diseases.
*Illustrative imageSkin resident memory T cells
Prof. Watanabe, a visiting professor in the same department, investigates how skin resident memory T cells affect various skin diseases, with the aim of developing therapeutics centered on normalizing T cell function. Prof. Watanabe also explores age-related changes in their function in healthy skin.
T cell subsets involved in connective tissue diseases
Lecturer Ueda in the same department sorts cells in the blood by type, by staining their surface markers with antibodies, and examines abnormalities in cell number and frequency, the presence of activation, functional abnormalities, and the association with skin lesions. The aim is to examine whether this can lead to elucidating the pathophysiology of connective tissue diseases and assessing disease status.
MembersFaculty
Members of the Department of Dermatology consist of a Professor, visiting professors, Lecturers, Assistant Professors, project faculty and researchers, graduate students, residents in specialty training, and registered clinical physicians.As of 2026
- ProfessorManabu Fujimoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Immunofluorescence light microscopy I” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Pathophysiology of connective tissue diseases and autoantibodies: “Systemic sclerosis case 09 pic 02” Nevit Dilmen (talk) / CC BY-SA 3.0 (cropped)
- B cells and skin diseases: “Human B Lymphocyte - NIAID” NIAID / CC BY 2.0 (cropped)
- Skin resident memory T cells: “Histology of thick skin” Bhavya akula / CC BY-SA 4.0 (cropped)
- Related lab (Mucosal Immunology Lab): “Culture Plates” Katherine Stember / CC BY 4.0 (cropped)
- Related lab (Cutaneous Allergy and Host Defense Lab): “Staphylococcus aureus 01” Photo Credit: Janice Carr Content Providers(s): CDC/ Matthew J. Arduino, DRPH; Janice Carr / Public domain (cropped)
- Related lab (Cellular Immunotherapy Lab): “Architektur eines chimären Antigenrezeptors (CAR)” Michels, A., Hartmann, J. & Buchholz, C.J. / CC BY 4.0 (cropped)
- Related lab (Immunology and Allergy Lab): “T Lymphocyte known as a T cell - 2231” NIAID / CC BY 2.0 (cropped)
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