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Immunology and Allergy Lab
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The lab focuses on group 2 innate lymphoid cells (ILC2) to explore the mechanisms of allergy and other conditions.
AboutAbout the lab
Aiming for research that changes history.
Moro Lab studies the immune cells called group 2 innate lymphoid cells (ILC2), which it was the first in the world to report, in 2010.
The lab approaches its research from multiple directions, from basic research on how ILC2 differentiate, are activated, and are suppressed, to drug discovery and development.
The lab is located at both the Osaka University Graduate School of Medicine and RIKEN, and students can conduct research at either one.
At the Immunology Frontier Research Center, the lab is listed as "Immunology and Allergy," while on the lab's own website it is listed as "Moro Lab."
Key terms
- Group 2 innate lymphoid cells (ILC2)
- Immune cells that are activated without recognizing antigens. They produce large amounts of type 2 cytokines and are involved in expelling parasites and in allergy.
- GATA3
- A transcription factor that this lab found to be critically important for the differentiation of ILC2.
- Steroid-resistant severe asthma
- Severe asthma in which symptoms occur even in the presence of steroids, when ILC2 are stimulated by TSLP in addition to IL-33.
NewsLab news
Admission policy posted for those hoping to enter the master's or doctoral program
An Assistant Professor joins in April, and a master's student joins the lab
A lab member won a Poster Award at the 25th Immunology Summer School 2024
A medical student won a Poster Award at the Japanese Cytokine Society JCS2024
ResearchResearch themes
Moro Lab studies group 2 innate lymphoid cells (ILC2), a new type of immune cell that the lab was the first in the world to report, in 2010. The lab carries out work consistently, from analysis of the basic functions of ILC2 to elucidating disease mechanisms and developing treatments, and hopes to contribute to understanding a variety of diseases.
*Illustrative imageInvestigating the differentiation and function of ILC2
The lab showed that ILC2 and their progenitors are present in peripheral tissues from the embryonic stage and differentiate there. It identified the importance of the transcription factor GATA3, and also studies the mechanisms of ILC2 activation and suppression.
*Illustrative imageMechanisms of allergy and new treatments
The lab showed that ILC2 play an important role even in steroid-resistant severe asthma, and found that suppressing ILC2 can relieve symptoms. It aims to establish new treatments that target ILC2.
*Illustrative imageLinks to other immune diseases and infections
The lab investigates the disease mechanisms of conditions involving ILC2, such as inflammatory bowel disease, Alzheimer's disease, and idiopathic interstitial pneumonia, and tests whether ILC2 could be a therapeutic target. It also studies defense responses against parasites, fungi, and influenza.
MembersFaculty
- ProfessorKazuyo Moro
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “T Lymphocyte known as a T cell - 2231” NIAID / CC BY 2.0 (cropped)
- Investigating the differentiation and function of ILC2: “Lymphoid cells and TB infection ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Mechanisms of allergy and new treatments: “Asthma Inhaler ( )” NIAID / CC BY 2.0 (cropped)
- Links to other immune diseases and infections: “Inflammatory Bowel Disease MTK” WolfpackBME / CC BY-SA 4.0 (cropped)
- Related lab (Immunochemistry Lab): “Westgate Microscopy t-lymphocytes” Cannons Law Firm, Glasgow, UK / CC BY 4.0 (cropped)
- Related lab (Cellular Immunotherapy Lab): “Architektur eines chimären Antigenrezeptors (CAR)” Michels, A., Hartmann, J. & Buchholz, C.J. / CC BY 4.0 (cropped)
- Related lab (Biochemistry and Immunology Lab): “WBCs, apoptosis and echinocytosis in peripheral blood smear, May-Grünwald stain” Bondarev.gal / CC BY 4.0 (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
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