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Stem Cell Biology and Developmental Immunology Lab
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The lab explores the bone marrow niche that supports blood and immune cells.
AboutAbout the lab
Exploring how the bone marrow microenvironment supports blood and immunity
The Stem Cell Biology and Developmental Immunology Lab studies the physiology and pathology of the microenvironment (niche) that maintains and regulates hematopoietic stem cells and immune cells in the bone marrow.
Tissue stem cells are special cells that can give rise to various mature cells and divide repeatedly, and they are responsible for maintaining tissues and regenerating damaged ones.
The lab discovered CAR cells, which form the hematopoietic stem cell niche in the bone marrow, and showed that CAR cells are also mesenchymal stem cells that give rise to osteoblasts and adipocytes.
In the Graduate School of Medicine's list of departments, Prof. Nagasawa's department is also listed under the name "Stem Cell Biology."
Key terms
- Hematopoietic stem cell
- A tissue stem cell in the bone marrow that gives rise to all blood cells and immune cells
- Niche
- A special microenvironment to which tissue stem cells adhere and are maintained; the number, proliferation, and differentiation of stem cells are regulated here
- Mesenchymal stem cell
- A stem cell that gives rise to bone-forming osteoblasts and to adipocytes. The lab showed that CAR cells are such cells
ResearchResearch themes
In the bone marrow, hematopoietic stem cells, the source of blood and immune cells, are maintained with the support of a special environment called the niche. The lab investigates at the cellular and molecular level how this niche forms and how it maintains and regulates hematopoietic stem cells and immune cells.
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MembersFaculty
The Stem Cell Biology and Developmental Immunology Lab's members consist of faculty and an administrative assistant (secretary).
- ProfessorTakashi Nagasawa
- Associate ProfessorYoshiki Omatsu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Micrograph of a red blood cell with basophilic stippling” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- The hematopoietic stem cell niche in the bone marrow: “Hematopoietic Stem Cell (NIH BioArt 199)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Malaria Immunology Lab): “Malaria falciparum ring forms” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (Immunoparasitology Lab): “Toxoplasma parasites (tachyzoites) in a fibroblast host cell” Morne Arin (Ksena Longrin, previously known as Kseniia Bondarenko) / CC BY 4.0 (cropped)
- Related lab (Human Single Cell Immunology Lab): “Lymph Node (NIH BioArt 304)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Cellular Immunotherapy Lab): “Architektur eines chimären Antigenrezeptors (CAR)” Michels, A., Hartmann, J. & Buchholz, C.J. / CC BY 4.0 (cropped)
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