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Pathogenic Bacteria Research Group Abe Lab
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A lab that analyzes the relationships among pathogenic bacteria, host immunity, and antimicrobial drugs.
AboutAbout the lab
Unraveling how pathogens, immunity, and antimicrobial drugs relate
The Pathogenic Bacteria Research Group (Abe Lab) analyzes the interrelationships among pathogenic bacteria, the host immunity that acts against them, and antimicrobial drugs.
Its goal is to contribute to proposing better diagnostic methods and treatment guidelines.
The lab studies the humoral bactericidal factors that act when bacteria enter the bloodstream, and the individual differences among pathogens.
The lab is also jointly carrying out research that uses genome analysis results of carbapenem-resistant bacteria collected in Thailand.
Key terms
- host immunity
- The immune functions of the infected body that eliminate pathogens
- humoral bactericidal factors
- Components contained in body fluids such as blood that attack bacteria directly, without the involvement of cells
- antimicrobial susceptibility testing
- A test that examines how much an antimicrobial drug suppresses the growth of bacteria
- carbapenem-resistant bacteria
- Bacteria that are resistant to carbapenem, a class of antimicrobial drugs
NewsLab news
Joint research with an Associate Professor at Ramathibodi Hospital (Mahidol University)
Started joint research with the Traumatology and Acute Critical Medicine division of Osaka University
Joint research with the Center for Supporting Drug Discovery and Life Science Research at Osaka University
The lab was established
ResearchResearch themes
Drug-resistant bacteria that antimicrobial drugs cannot kill are rapidly increasing around the world, yet properly diagnosing bacterial infections and using antimicrobial drugs appropriately is still not easy in clinical practice today. The lab analyzes the interrelationships among pathogenic bacteria, the host immunity that acts against them, and antimicrobial drugs, and aims to contribute to proposing better diagnostic methods and treatment guidelines.
*Illustrative imageIndividual differences in pathogens and humoral bactericidal factors
What happens when bacteria enter the bloodstream varies with the combination of the bacterium and the host's immunity. The lab studies how pathogens and humoral immunity interact before cellular immunity comes into play, what causes individual differences, and how they affect clinical care.
*Illustrative imageRelationships among pathogens, host immunity, and antimicrobial drugs
In clinical practice, antimicrobial drugs are chosen by checking whether bacterial growth is suppressed in an artificial nutrient medium, and host factors are not taken into account. The lab's goal is to eventually demonstrate an antimicrobial susceptibility test that evaluates host factors, pathogens, and antimicrobial drugs together.
*Illustrative imageSpread of carbapenem-resistant bacteria in Thailand
Together with the Drug-Resistant Bacteria Division of the Japan–Thailand Research Collaboration Center on Emerging and Re-emerging Infections, the lab uses carbapenem-resistant bacteria collected in Thailand and the results of their genome analysis to study the mechanisms of spread, resistance, and virulence factors.
MembersFaculty
The members of the Abe Lab consist of faculty, project researchers, graduate students, research students, technical staff, and secretaries.As of 2026
- Project Associate ProfessorRyuichiro Abe
- Project Assistant ProfessorLian Zheng Jie
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Antimicrobial susceptibility testing (AST) result of Leuconostoc” Ajay Kumar Chaurasiya / CC0 (cropped)
- Individual differences in pathogens and humoral bactericidal factors: “Neutrophils with intracellular bacteria on peripheral blood smear” Spicy / CC BY-SA 4.0 (cropped)
- Relationships among pathogens, host immunity, and antimicrobial drugs: “Antibiotic sensitivity testing” Bondarev.gal / CC BY 4.0 (cropped)
- Spread of carbapenem-resistant bacteria in Thailand: “Genome-analysis-pipeline” Beatrice Branchini / CC BY 4.0 (cropped)
- Related lab (Zoonotic Bacterial Infections Research Group Tsukamoto Lab): “15985 lores” CDC/ Sheila Mitchel / Public domain (cropped)
- Related lab (Iwasaki Lab): “Lassa Virus” NIAID / CC BY 2.0 (cropped)
- Related lab (Kodama Lab): “E. coli Bacteria ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (Fujimoto Lab): “Phosphate solubilizing bacteria cultured in petri dish” Joydeep / CC BY-SA 3.0 (cropped)
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