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Vaccine Creation Group Yoshioka Lab
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A lab that develops safe and effective vaccines from a pharmaceutical sciences perspective.
AboutAbout the lab
Learn from vaccines, master vaccines, create vaccines.
The Vaccine Creation Group Yoshioka Lab researches the development of new vaccines against infectious diseases.
Based on drug delivery science, safety science and toxicology, and protein engineering, the lab aims to achieve both strong vaccine efficacy and a level of safety and reassurance that allows people of all ages and genders to be vaccinated.
Currently, the lab works on mRNA vaccines with reduced adverse reactions, intranasal vaccines, and antigen design based on structural vaccinology, and has also begun work on mRNA vaccines against cancer.
In collaboration with the Research Foundation for Microbial Diseases of Osaka University (BIKEN), a leading company in vaccine development, the lab aims to create "the vaccines of 10 years from now."
Key terms
- Adjuvant
- A substance added to a vaccine to strengthen the immune response. Also called an immunostimulant
- Lipid nanoparticle (LNP)
- A tiny particle made of lipids that encapsulates mRNA
- Intranasal vaccine
- A vaccine administered into the nasal cavity. It can induce antibody production in the upper respiratory tract, the entry point of infection
NewsLab news
Undergraduate students received the Best Young Researcher Encouragement Award and other awards at the Joint Annual Meeting of the Japanese Society for Vaccinology and the Japanese Society for Clinical Virology
A paper first-authored by a researcher was published in Vaccine
A researcher received the Excellent Presenter Award at the 42nd Annual Meeting of the Japanese Society of Drug Delivery System
A first-author paper was published in Mol Ther Nucleic Acids
Project Professor Yasuo Yoshioka received the 50th Isamu Tagaya Memorial Vaccine Research Iskra Encouragement Award
ResearchResearch themes
In vaccine development, major problems are the need for suitable carriers to deliver antigens to immune cells and the slow progress in developing adjuvants that strengthen the immune response. Based on integrated collaboration among pharmaceutical sciences, medicine, and science and engineering, the lab works to overcome these challenges and develop effective and safe vaccines.
*Illustrative imagemRNA vaccines with fewer adverse reactions
Vaccines in which mRNA is encapsulated in lipid nanoparticles (LNPs) frequently cause adverse reactions such as fever and swelling at the injection site. The lab is developing mRNA vaccines with fewer adverse reactions by modifying LNPs and other components.
*Illustrative imageIntranasal vaccines
Intranasal vaccines, which are administered into the nasal cavity, are expected to be vaccines that can prevent infection itself. Taking into account the problem that antigens have difficulty passing through the mucosal barrier of the nasal cavity, the lab is developing antigen delivery technologies that can efficiently induce mucosal immunity.
*Illustrative imageEnterovirus D68 vaccines
Enterovirus D68 is a pathogen that causes respiratory symptoms, and in recent years it has been suggested to be associated with polio-like paralysis. No vaccine exists yet, and the lab is attempting to develop inactivated whole-particle vaccines, mRNA vaccines, and virus-like particle (VLP) vaccines.
*Illustrative imageAntigen design through structural vaccinology
This field uses information on the three-dimensional structure of vaccine antigens to give antigens functions such as improved thermal stability and higher expression levels and yields. Through interdisciplinary collaboration with protein engineering experts, the lab is pursuing optimal antigen design.
MembersFaculty
The members of the Vaccine Creation Group Yoshioka Lab consist of faculty, project researchers, researchers, doctoral and undergraduate students, and administrative assistants.As of 2026
- Project ProfessorYasuo Yoshioka
- Project LecturerToshiro Hirai
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Vero Cell COVID-19 vaccine vial, cotton swab and syringe” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- mRNA vaccines with fewer adverse reactions: “Solo-mrna-vaccine-5” Spencerbdavis / CC BY 4.0 (cropped)
- Intranasal vaccines: “GI receives an intranasal mist of the flu vaccine at Guantanamo” Elisha Dawkins / Public domain (cropped)
- Enterovirus D68 vaccines: “Enterovirus D68 Virus” NIAID / CC BY 2.0 (cropped)
- Antigen design through structural vaccinology: “Protein design” Vara104 / CC BY-SA 4.0 (cropped)
- Related lab (ウイルスワクチングループ): “Electron micrograph of smallpox virus” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (マラリアワクチン開発研究グループ 堀井研究室): “Plasmodium falciparum smear” Paulo Henrique Orlandi Mourao / CC BY-SA 3.0 (cropped)
- Related lab (感染腫瘍制御分野 幸谷研究室): “Epstein-Barr Virus (EBV) Particles” NIAID / CC BY 2.0 (cropped)
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