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Virus Infection Lab
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The lab studies mosquito-borne viruses and norovirus in collaboration with researchers in Thailand.
AboutAbout the lab
Studying Asia's viral infections together with Thai researchers.
The lab studies viral intestinal infections and mosquito-borne infections that recur in Asian countries, including Thailand and Japan.
As a division of the Japan-Thailand Joint Research Center for Infectious Diseases, the lab carries out its research together with researchers at the Department of Medical Sciences, Ministry of Public Health of the Kingdom of Thailand.
Among mosquito-borne viruses, the lab focuses on antibody-dependent enhancement (ADE) of dengue virus infection.
For intestinal infections, the lab studies norovirus, a cause of acute gastroenteritis, aiming to track changes in circulating strains and to clarify its life cycle.
Key terms
- ADE
- Short for antibody-dependent enhancement of infection. A phenomenon in which antibodies against a virus end up strengthening the viral infection instead.
- Cohort study
- A study that follows a group of people over a certain period to examine the course of a disease and the factors involved.
- SRIP
- Short for Single Round Infectious Particle. A particle that infects a cell only once.
ResearchResearch themes
For mosquito-borne viruses, establishing infection countermeasures based on basic research is considered a challenge in epidemic prevention, and the lab focuses on ADE of dengue virus. The lab also works to clarify changes in circulating norovirus strains and the norovirus life cycle.
*Illustrative imageResearch on ADE of dengue virus
The lab focuses on ADE in dengue virus, which causes dengue fever and severe dengue hemorrhagic fever. It conducts a cohort study aimed at predicting progression to severe disease, and analyzes factors involved in ADE.
*Illustrative imageNorovirus epidemics and diversification
How norovirus diversifies and persists in human society is not yet well understood. The lab identifies genomic mutations in circulating strains through epidemiological surveys, aiming to clarify the norovirus life cycle.
*Illustrative imageDevelopment of a rapid ADE assay
Conventional ADE assays required considerable time and labor for staining infected cells and counting them under a microscope. The lab developed a method that uses single-round infectious particles (SRIPs) as the antigen, which simplifies the latter steps and gives results in less time.
MembersFaculty
The members of the Virus Infection Lab consist of a Professor and a Project Lecturer.
- Professor (Concurrent)Takeshi Kobayashi
- Project LecturerAtsushi Yamanaka
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aedes aegypti on leaf” Wee Hong / CC BY-SA 4.0 (cropped)
- Research on ADE of dengue virus: “Aedes Mosquito and Dengue Virus Particles” NIAID / CC BY 2.0 (cropped)
- Norovirus epidemics and diversification: “Eppendorf Mastercycler Pro S” GFJ / CC BY-SA 4.0 (cropped)
- Development of a rapid ADE assay: “96 well plate” J.N. Eskra / CC BY-SA 4.0 (cropped)
- Related lab (Bacterial Infection Division Lab): “Vibrio cholerae-Darting motility, Gram stain, Culture on solid and liquid media, and Preservation” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Osaka-Mahidol Infectious Diseases Center Lab): “Aedes aegypti biting human” Original author: US Department of Agriculture; then denoised rescaled, enhanced with adaptive denoising filters and minimal resharpening, then unscaled to original resolution, for easier refitting at various resolutions. / Public domain (cropped)
- Related lab (Drug-Resistant Bacteria Lab): “Proteus mirabilis petri” Dr. John J. Farmer / Public domain (cropped)
- Related lab (Kobayashi Lab): “Multiple rotavirus particles” Dr Graham Beards / CC BY 3.0 (cropped)
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