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Virus Vaccine Group
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A lab that uses virus research to create vaccines for infectious diseases that are difficult to develop vaccines for.
AboutAbout the lab
Taking on hard-to-vaccinate infectious diseases through virus research.
The Virus Vaccine Group conducts virus research targeting infectious diseases for which no vaccines have been developed so far.
Its targets include infectious diseases caused by pathogens that cannot be controlled by humoral immunity alone or that cannot be cultured, and diseases for which there is no animal model, making it difficult to evaluate efficacy.
The goal is to develop a "world-first vaccine from Japan."
The group is part of the BIKEN Next-Generation Vaccine Collaborative Research Institute, and through collaboration with the BIKEN Foundation, it pursues both basic and applied research.
Key terms
- Humoral immunity
- An immune mechanism in which antibodies produced in body fluids such as blood protect against pathogens
- Viral vector vaccine
- A vaccine that uses another virus as a carrier to deliver vaccine components into the body
- Live attenuated vaccine
- A vaccine that uses a live virus with reduced virulence
ResearchResearch themes
The Virus Vaccine Group conducts virus research targeting infectious diseases for which no vaccines have existed so far, with the goal of developing a "world-first vaccine from Japan." Because of the nature of vaccine research, the group handles a wide variety of viruses.
*Illustrative imageLaying the groundwork for next-generation vaccines
Using virus engineering techniques, the lab conducts research on viral vector vaccines, nucleic acid vaccines, replicon vaccines, VL vaccines, and more. It aims to create the foundation for new vaccines that are powerful and safe, with no adverse effects on either the human body or the natural environment.
*Illustrative imageViral adaptation and live attenuated vaccines
Adapting a virus to a different host or to living conditions such as temperature can change its properties. The lab holds that by pursuing this "Viruses adaptation" in depth, live attenuated vaccines can be created.
*Illustrative imageCoexistence and heterogeneity among viruses
The lab focuses on the ecology of viruses that cannot replicate on their own and survive by relying on other viruses. It hopes to understand the ecology of entities such as defective viral genomes and adeno-associated viruses, and to apply that understanding to vaccines.
MembersFaculty
- Project Assistant ProfessorShinya Okamura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Electron micrograph of smallpox virus” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Laying the groundwork for next-generation vaccines: “Solo-Viral Vector-vaccine-27” Spencerbdavis / CC BY 4.0 (cropped)
- Viral adaptation and live attenuated vaccines: “Embryonated chicken egg-10759 lores” CDC/ Laura R. Zambuto, James Gathany / Public domain (cropped)
- Coexistence and heterogeneity among viruses: “Effects of a bottleneck on virus populations” Naomi L. Forrester, Lark L. Coffey and Scott C / CC BY 4.0 (cropped)
- Related lab (Vaccine Creation Group Yoshioka Lab): “Vero Cell COVID-19 vaccine vial, cotton swab and syringe” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (Kobayashi Lab): “Multiple rotavirus particles” Dr Graham Beards / CC BY 3.0 (cropped)
- Related lab (Iwasaki Lab): “Lassa Virus” NIAID / CC BY 2.0 (cropped)
- Related lab (Watanabe Lab): “Influenza A Virus (H3N )” NIAID / CC BY 2.0 (cropped)
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