Labs in The University of Osaka

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The lab supports health promotion through lifestyle habits such as diet and exercise.

The Lifestyle Medicine Lab investigates, through clinical research, how lifestyle habits such as diet, exercise, and sleep are associated with health. Based on evidence from nutritional epidemiology, the lab develops lifestyle improvement programs that people can enjoyably incorporate into daily life, with the aim of using them in clinical settings. The lab also examines, in clinical studies in humans, the health effects of dashi and fermented foods, which have traditionally been used in Japanese food culture. The lab is established as an endowed department, funded by donations, within the Graduate School of Medicine.

#Lifestyle modification #Digital therapeutics #Dashi and fermented foods

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The lab develops new treatments and medical devices for interventional radiology (IVR).

The High-Precision Image-Guided Puncture Therapy Lab is an endowed department that uses translational research to develop innovative treatments and medical devices for interventional radiology (IVR). Its work in IVR includes research on drug delivery focused on tumor immunity and metabolism, development of liquid embolic materials, and development of CT-guided marking agents. In recent work, the lab has developed a Lipiodol Pickering emulsion that slowly releases anti-PD-L1 antibody, an immune checkpoint inhibitor, and is considering its application to the treatment of hepatocellular carcinoma.

#Interventional radiology (IVR) #Liquid embolic agents #Drug delivery

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The lab designs adipose-derived stem cells to explore treatments for conditions such as cerebral infarction.

The Gene and Stem Cell Regenerative Therapeutics Lab aims to develop treatments using “designer cells”: adipose-derived stem cells into which genes have been inserted to enhance their function. Its main targets are cerebral infarction and autoimmune diseases. The lab also searches for new molecules that suppress inflammation and studies immunity against cancer. Established as an endowed department in January 2023, the lab is small but also conducts joint research with orthopedic surgery. In joint research with AS Medical Support Co., Ltd., the lab analyzed cells supplied by the company and found that the amount of hepatocyte growth factor (HGF) varies between individuals, which may affect therapeutic efficacy.

#Adipose-derived stem cells #Cerebral infarction #Tumor immunology

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The lab takes on the diagnosis and drug discovery of intractable diseases such as cancer through data analysis.

The Disease Data Science Lab conducts research on biomarker technologies, drug discovery technologies, and post-launch drug optimization technologies (ikuyaku) for intractable diseases such as cancer. By analyzing large-scale data (big data) with computers, the lab aims to pursue everything in one continuous process, from molecular profiling to drug discovery and clinical application. The lab is a joint research chair funded by companies and medical corporations, and it conducts research in collaboration with core departments such as Gastroenterological Surgery. Graduate students who want to pursue a full-fledged research career in the future are welcome to join.

#Biomarkers #Epigenome drug discovery #Cancer stem cells

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A joint research chair that aims to develop treatments for intractable neurological diseases.

The Drug Discovery Neuroscience Joint Research Chair is a chair in which researchers from the Osaka University Graduate School of Medicine and Tanabe Pharma work together on research to develop treatments for intractable neurological diseases. The lab analyzes the pathology of various neurological diseases, searches for drug targets based on the results, and evaluates the efficacy of new drug candidates using disease model animals. It also searches for biomarkers that make it possible to evaluate the effects of new drug candidates accurately and quickly in clinical trials. Making use of Osaka University's state-of-the-art imaging analysis facilities and more, the lab aims to create new value and achieve innovative drug discovery.

#Intractable neurological diseases #Biomarkers #Drug targets

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The lab builds new evidence by integrating real-world data with clinical trials.

The Medical Data Science Joint Research Chair is a lab that sets out to build new evidence by integrating real-world data with clinical trials. Together with the Department of Medical Statistics and the Data Center of the Department of Medical Innovation, it operates as part of the Osaka University medical statistics group. The lab works on developing methods to build optimal evidence from real-world data and use it for decision-making. It is also building a foundation of medical statistics literacy and training the highly specialized professionals that medical research requires.

#Real-world data #Clinical trials #Medical statistics

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The lab is a joint research chair that works to bring AI-based systems supporting diagnosis from medical images into clinical practice.

The Joint Research Chair of Artificial Intelligence in Diagnostic Radiology researches the use of artificial intelligence in computer-aided diagnosis (CAD), which supports physicians' diagnosis based on medical images. Together with companies, the lab tackles the challenges involved in developing AI-based CAD: preparing training data, developing high-accuracy systems, and incorporating them into the clinical workflow. The lab also develops AI technologies that handle the problem of limited case numbers, as well as explainable AI, aiming for practical use of next-generation AI-CAD.

#Computer-aided diagnosis #Deep learning #Explainable AI

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The lab is a joint research chair that studies technologies for measuring and reconstructing brain function.

The Joint Research Chair of Brain Function Diagnosis and Reconstruction (Hirata Lab) researches and develops technologies for measuring, reconstructing, and controlling brain function, with the aim of diagnosing and reconstructing it. Project Professor Hirata, who heads the chair, has studied how the brain works using magnetoencephalography and applied it to examinations, and has worked on the research and development of brain-machine interfaces, which reconstruct brain function by engineering methods. Through joint research with a group of companies, the lab aims for technologies that can be put into practical medical use, such as wireless devices implanted in the body. Project Professor Hirata completed graduate school in engineering and worked as an engineer at a company, then switched to medicine and became a neurosurgeon.

#Brain-machine interfaces #Magnetoencephalography #Implantable devices

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The lab develops treatments for intractable diseases by targeting pathological forms of periostin.

The Advanced Molecular Therapeutics Lab researches the development of treatments for intractable diseases that target pathological forms of a protein called periostin. Several splicing variants, in which exons are missing, are produced from the periostin gene. It has become clear that among them are forms that play physiological roles, and forms that appear in disease and either worsen or improve the pathology. The lab investigates the role of periostin in heart failure, aneurysm, cancer, cerebral infarction, and other conditions, and connects this to the development of treatments.

#Periostin #Splice variants #Intractable diseases

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附属未来医療イメージングセンター (introduction coming soon)

We're preparing this lab's page. You can check its research on the lab's official website.