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Advanced Molecular Therapeutics Lab
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The lab develops treatments for intractable diseases by targeting pathological forms of periostin.
AboutAbout the lab
Developing treatments for intractable diseases by targeting pathological periostin.
The Advanced Molecular Therapeutics Lab researches the development of treatments for intractable diseases that target pathological forms of a protein called periostin.
Several splicing variants, in which exons are missing, are produced from the periostin gene.
It has become clear that among them are forms that play physiological roles, and forms that appear in disease and either worsen or improve the pathology.
The lab investigates the role of periostin in heart failure, aneurysm, cancer, cerebral infarction, and other conditions, and connects this to the development of treatments.
Key terms
- Periostin
- A protein found in various organs, involved in cell proliferation and tissue repair.
- Splicing variant
- Multiple forms produced from the same gene when parts of it (exons) are skipped or retained.
- Neutralizing antibody
- An antibody that suppresses the activity of its target. The lab is making one that targets only pathological periostin.
NewsLab news
A project researcher received the Best Presentation Award at the Annual Meeting of the Japan Society of Anti-Aging Medicine
Prof. Taniyama published the content of a special lecture as a review article in Osaka Hokeni Zasshi (Osaka Insurance Physicians Journal)
Together with the Department of Breast and Endocrine Surgery, the lab announced the start of a clinical trial of an antibody against pathological periostin
A graduate student who is a joint research collaborator received the Excellent Presentation Award at the Annual Meeting of the Japanese Society of Oral and Maxillofacial Surgeons
A paper examining periostin expression in normal tissue and breast cancer was published in Biomolecules
ResearchResearch themes
The research started when a comprehensive search in a heart failure model for genes that change in common as the disease progresses led to the periostin gene. Targeting the pathological forms, which appear in disease, among the splicing variants produced from this gene, the lab develops treatments for a variety of intractable diseases.
*Illustrative imageSuppressing the worsening of heart failure
The lab confirmed that PN1, one form of periostin, increases in heart failure and promotes changes in heart tissue (remodeling). When a neutralizing antibody against PN1 was administered starting the day after acute myocardial infarction, the infarct size shrank and cardiac function improved.
*Illustrative imageHow aneurysms form
The lab created models of various aneurysms and found that periostin is overexpressed in the blood vessels during the process of aneurysm formation. It reported that aneurysm formation improved in PNKO mice lacking the periostin gene, and is analyzing the mechanism of action.
*Illustrative imageChemotherapy resistance in cancer
The lab found that cancer cells secrete periostin to escape the attack of anticancer drugs and become cancer stem cells. In a breast cancer model, using a neutralizing antibody that suppresses only pathological periostin almost eliminated resistance to chemotherapy.
*Illustrative imageProtective effect in cerebral infarction
The lab showed that administering PN2, another form of periostin, to mice with cerebral infarction shrinks the infarct size, and confirmed a protective effect on neurons as the mechanism. It also confirmed that PN1 does not have this effect, and is analyzing the difference between PN1 and PN2.
MembersFaculty
The members of the Advanced Molecular Therapeutics Lab consist of faculty, a Visiting Associate Professor, project researchers, researchers, and joint research members.As of 2026
- Project ProfessorYoshiaki Taniyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cardiovascular system - Systolic heart failure -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Suppressing the worsening of heart failure: “Cardiovascular system - Diastolic heart failure -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- How aneurysms form: “Diseased Blood Vessel Model ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Chemotherapy resistance in cancer: “Cancer stem cells model” Malymajo / CC BY-SA 3.0 (cropped)
- Protective effect in cerebral infarction: “FLAIR MRI of cerebral infarction” edit Shazia Mirza and Sankalp Gokhale See also source article for additional image creators. / CC BY 4.0 (cropped)
- Related lab (Clinical Gene Therapy Lab): “AAV Gene Therapy” George Church / CC BY-SA 3.0 (cropped)
- Related lab (Disease Data Science Lab): “Cdnaarray” Mangapoco / CC BY 2.5 (cropped)
- Related lab (Visual Function Reconstruction Lab): “EpiretinalMembrane OCT” Jmarchn / CC BY-SA 3.0 (cropped)
- Related lab (Metabolism and Vascular Medicine Lab): “Histopathology of coronary artery atherosclerosis, original” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
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