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High-Precision Image-Guided Puncture Therapy Lab
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The lab develops new treatments and medical devices for interventional radiology (IVR).
AboutAbout the lab
Developing new treatments and medical devices for IVR
The High-Precision Image-Guided Puncture Therapy Lab is an endowed department that uses translational research to develop innovative treatments and medical devices for interventional radiology (IVR).
Its work in IVR includes research on drug delivery focused on tumor immunity and metabolism, development of liquid embolic materials, and development of CT-guided marking agents.
In recent work, the lab has developed a Lipiodol Pickering emulsion that slowly releases anti-PD-L1 antibody, an immune checkpoint inhibitor, and is considering its application to the treatment of hepatocellular carcinoma.
Key terms
- Interventional radiology (IVR)
- Treatment performed while viewing the inside of the body through imaging. This lab develops treatment methods and medical devices for it.
- DDS
- Short for drug delivery system. A technology that devises how a drug is delivered, such as carrying it to the target site and releasing it slowly.
- Immune checkpoint inhibitor
- A drug used to maintain the immune response against cancer. The one this lab works with is anti-PD-L1 antibody.
ResearchResearch themes
The lab uses translational research to develop innovative treatments and medical devices for interventional radiology (IVR). It studies drug delivery focused on tumor immunity and metabolism, liquid embolic materials, and formulations and devices for non-vascular IVR.
*Illustrative imageIVR focused on tumor immunity and metabolism
Focusing on tumor immunity and metabolism, the lab conducts molecular biological research related to the drug delivery of agents that modulate immunity and metabolism through IVR.
*Illustrative imageNon-adhesive liquid embolic material with minimal foreign-body reaction
The lab is developing a liquid embolic material that, unlike existing ones, is non-adhesive and causes little foreign-body reaction.
*Illustrative imageFormulations and devices for non-vascular IVR
The lab develops new formulations and devices for non-vascular IVR. Examples include a CT-guided marking agent and an ablation device for small animals.
*Illustrative imageA drug delivery system (DDS) for sustained release of anti-PD-L1 antibody
To enhance the effect of cancer immunotherapy for hepatocellular carcinoma, the lab is developing a Lipiodol Pickering emulsion that releases anti-PD-L1 antibody in a sustained manner. In vitro experiments produced a formulation with excellent sustained-release performance, and hepatic arterial injection in a rat model of hepatocellular carcinoma is planned.
MembersFaculty
- Lecturer, Endowed ChairYasushi Kimura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Interventional radiology” Elena Escalante Porrua / CC BY-SA 4.0 (cropped)
- IVR focused on tumor immunity and metabolism: “Interventional radiology A” Navy Medicine / Public domain (cropped)
- Non-adhesive liquid embolic material with minimal foreign-body reaction: “Control post-embolització amb coils del sagnat de l'artèria gastroduodenal” Mbarrufet / CC BY-SA 4.0 (cropped)
- Formulations and devices for non-vascular IVR: “Tube à Rayon X dans un hôpital au Bénin 05” Adoscam / CC BY-SA 4.0 (cropped)
- A drug delivery system (DDS) for sustained release of anti-PD-L1 antibody: “Bio-inspired hybrid multifunctional drug delivery system (cropped)” Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic and Fabio Zobi / CC BY-SA 4.0 (cropped)
- Related lab (Clinical Gene Therapy Lab): “AAV Gene Therapy” George Church / CC BY-SA 3.0 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Disease Data Science Lab): “Cdnaarray” Mangapoco / CC BY 2.5 (cropped)
- Related lab (Advanced Vision Medicine Lab): “Optical coherence tomography conducted using the Ultreon 1.0 Software” Cath Lab / CC BY-SA 4.0 (cropped)
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