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Gene and Stem Cell Regenerative Therapeutics Lab
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The lab designs adipose-derived stem cells to explore treatments for conditions such as cerebral infarction.
AboutAbout the lab
Designing stem cells to pursue new treatments
The Gene and Stem Cell Regenerative Therapeutics Lab aims to develop treatments using “designer cells”: adipose-derived stem cells into which genes have been inserted to enhance their function.
Its main targets are cerebral infarction and autoimmune diseases. The lab also searches for new molecules that suppress inflammation and studies immunity against cancer.
Established as an endowed department in January 2023, the lab is small but also conducts joint research with orthopedic surgery.
In joint research with AS Medical Support Co., Ltd., the lab analyzed cells supplied by the company and found that the amount of hepatocyte growth factor (HGF) varies between individuals, which may affect therapeutic efficacy.
Key terms
- Adipose-derived stem cells
- Stem cells obtained from adipose tissue. They secrete various cytokines.
- Hepatocyte growth factor (HGF)
- A cytokine secreted by cells. In adipose-derived stem cells, the amount varies greatly between individuals.
- Tumor microenvironment
- The environment formed around a cancer. Factors associated with tumor growth are produced there, and antitumor immunity is suppressed.
NewsLab news
Paper on FAP, a novel inflammation-regulating factor in cerebral infarction, published in Journal of Cerebral Blood Flow & Metabolism
Paper on the antitumor effect of the peptide MHP1 accepted by Anticancer Research
ResearchResearch themes
The lab aims to develop treatments using designer cells made from adipose-derived stem cells. Targeting cerebral infarction, autoimmune diseases, and cancer, it investigates the mechanisms and molecules that regulate inflammation and immunity.
Treating cerebral infarction with designer cells
In joint research, the lab found that the amount of hepatocyte growth factor (HGF) secreted by adipose-derived stem cells varies between individuals, and that cells with low HGF were less effective at improving paralysis in mice with cerebral infarction. The lab is developing cells carrying genes that strengthen HGF and also enhance the cells' ability to migrate to the lesion.
*Illustrative imageSearching for novel molecules that suppress inflammation
The lab is searching for new anti-inflammatory molecules that could help treat cerebral infarction. A partial peptide of RANKL showed therapeutic effects in conditions such as sepsis and psoriasis, and FAP was found to be a molecule that suppresses inflammation in cerebral infarction and protects neurons.
*Illustrative imageDeveloping treatments that enhance cancer immunity
The lab stimulates the tumor microenvironment with immunostimulants and molecularly targeted drugs to release the suppression of antitumor immunity and overcome resistance to PD-1 antibody therapy. It has developed a whole-cell cancer vaccine with an improved manufacturing process, aiming to prevent cancer metastasis and recurrence.
MembersFaculty
The lab's members include faculty members, visiting professors, research students, technical assistants, and administrative assistants.As of 2026
- Professor, Endowed ChairMunehisa Shimamura
- Assistant Professor, Endowed ChairJinyang Zhang
- Assistant Professor, Endowed ChairNan Ju
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “AA01946a” SozvezdieL / CC BY 4.0 (cropped)
- Searching for novel molecules that suppress inflammation: “Fluorescently labeled, DAPI-stained cell nuclei in a mouse coronal brain section” Syed07 / CC BY 4.0 (cropped)
- Developing treatments that enhance cancer immunity: “Tumor microenvironment” Frontiers in Oncology / CC BY 3.0 (cropped)
- Related lab (Clinical Gene Therapy Lab): “AAV Gene Therapy” George Church / CC BY-SA 3.0 (cropped)
- Related lab (Drug Discovery Neuroscience Lab): “Drug discovery cycle 2” Boghog / CC BY-SA 4.0 (cropped)
- Related lab (Disease Data Science Lab): “Cdnaarray” Mangapoco / CC BY 2.5 (cropped)
- Related lab (Applied Stem Cell Medicine Lab): “Cell Culture in a tiny Petri dish” kaibara87 / CC BY 2.0 (cropped)
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