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451 labs · 35 student voices
Manabu Nakayama, Professor
0 student voices
The Genetic Drug Discovery Lab is a collaborative chair (pharmacy) of Chiba University's Graduate School of Medical and Pharmaceutical Sciences, and its faculty members are affiliated with the Kazusa DNA Research Institute. The lab develops genome engineering technologies and uses them to create disease model mice. To identify genes associated with common human diseases, the lab is building a pipeline for producing conditional knockout mice. The lab also conducts research to comprehensively investigate the functions of a group of very large proteins expressed in the nervous system.
Tomoya Uehara, Professor
0 student voices
The Molecular Imaging Pharmaceutics Lab studies the development of radiopharmaceuticals, which are drugs that use radionuclides (RI). Depending on the type of radiation used, a radiopharmaceutical can serve either as a diagnostic agent that detects disease through imaging or as a therapeutic agent that treats cancer. For early diagnosis of cancer and early assessment of treatment effects, the lab is developing drugs that allow changes inside cells to be captured in images from outside the body. In collaboration with Osaka University and other institutions, the lab is also working on developing cancer therapeutics that use astatine-211, which emits alpha radiation.
Yasumitsu Ogra, Professor
0 student voices
The Preventive Pharmacy Lab studies how chemical substances, especially metal compounds, affect human health. Even essential metals that the body needs are harmful in excess, and even toxic metals do not show toxicity below a certain concentration. The lab examines, step by step, how metals are taken up, transported, function, and are excreted in the body, aiming to clarify how the body regulates metals. The lab's facilities include instruments for elemental analysis, such as an ICP mass spectrometer and atomic absorption spectrophotometers.
Daisuke Nakajima, Professor
0 student voices
The Environmental Risk Lab is a collaborative program of the Graduate School of Medical and Pharmaceutical Sciences (Pharmaceutical Sciences) at Chiba University, and its partner institution is the National Institute for Environmental Studies. The faculty's primary appointments are at the partner institution, the National Institute for Environmental Studies. The lab's field is the assessment of chemical exposure and the effects of that exposure on living organisms. Its research areas include developing methods for comprehensive analysis of exposure to many kinds of chemicals, including newly emerging ones, and developing human biomonitoring methods. Using analytical toxicology methods, the lab also works to clarify the metabolic mechanisms of metalloid elements.
Hiroyuki Nakamura, Professor
0 student voices
The Pharmacodynamics Lab studies receptors and intracellular signal transduction to search for therapeutic targets and drug candidates for diseases. Many drugs in use today act on receptors or block ion channels. The lab focuses in particular on the pharmacological actions of molecules related to sphingolipids such as sphingosine and ceramide. It is also working on developing treatments for rare and intractable diseases such as Niemann-Pick disease type C and multiple sclerosis.
Hiroto Hatakeyama, Professor
0 student voices
The Drug Science Lab studies next-generation drugs, focusing on how drugs move within the body and cells and where they end up. Its subjects are antibody drugs such as immune checkpoint inhibitors used in cancer immunotherapy, and nucleic acid drugs that use lipid nanoparticles. Much remains unknown about how drug effects and side effects arise, so the lab pursues both basic research grounded in clinical problems and applied research aimed at practical use. The lab accepts inquiries about lab visits, but applicants from outside who wish to enter its graduate school are limited to those hoping to go on to a PhD.
Kosei Ito, Professor
0 student voices
The Biopharmaceutics Lab studies the pharmacokinetics of drugs and drug candidate compounds (how they behave in the body) and their adverse effects, such as side effects. Even when no problems appear in test tubes or mice, unexpected side effects often emerge only once a drug is used in humans. The lab aims to clarify the mechanisms of side effects at the molecular level and, on that basis, to develop methods for predicting them in advance. It focuses in particular on injury to the liver, the central organ for drug metabolism and excretion.
Yuko Sekine, Professor
0 student voices
The Pharmacy Practice Lab identifies problems that arise in pharmacists' work and conducts research to put evidence-based proper use of drugs into practice. In clinical practice, there are many drugs that have long been used without clear evidence, and many areas, such as managing side effects, where evidence has not been established. The lab believes it is essential for pharmacists, as scientists, to take part in drug therapy by presenting evidence. Through research, the lab aims to train clinical pharmacists who will be central to future drug therapy.
Itsuko Ishii, Professor
0 student voices
The Clinical Pharmaceutics Lab works with Chiba University Hospital and conducts research with the clinical setting close at hand. To help patients use the drug best suited to them safely, the lab looks at drugs through a "chemical lens" and places importance on identifying risks. The professor believes that pharmacists of the future should contribute to patients' drug therapy on the wards together with physicians and nurses. The professor holds that personalized medicine can be realized by proposing blood drug concentration measurement and genetic testing.
Shingo Yamazaki, Professor
0 student voices
The Clinical Pharmacotherapeutics Lab conducts research aimed at optimizing drug therapy, meaning better ways of using drugs, and at generating new information on the effects and safety of drugs. By combining "wet-lab research," which measures and analyzes drug concentrations, with "dry-lab research," which analyzes patient data, the lab tackles problems in clinical practice. Under pharmacist faculty members who also hold posts at the University Hospital, the lab carries out clinically relevant research whose results can be returned to patients. Through this research, the lab trains clinical pharmacists who can think about how to use drugs in a way that suits each individual patient.
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