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Drug Science Lab
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A lab investigating how antibody drugs and nucleic acid drugs are delivered within the body.

AboutAbout the lab
A drug works only once it arrives
The Drug Science Lab studies next-generation drugs, focusing on how drugs move within the body and cells and where they end up.
Its subjects are antibody drugs such as immune checkpoint inhibitors used in cancer immunotherapy, and nucleic acid drugs that use lipid nanoparticles.
Much remains unknown about how drug effects and side effects arise, so the lab pursues both basic research grounded in clinical problems and applied research aimed at practical use.
The lab accepts inquiries about lab visits, but applicants from outside who wish to enter its graduate school are limited to those hoping to go on to a PhD.
Key terms
- Immune checkpoint inhibitor
- An antibody drug that releases the brake that cancer cells place on the immune system, allowing T cells to attack the cancer
- Lipid nanoparticle
- A very small particle made of lipids. It encapsulates nucleic acids such as mRNA and carries them into cells
- Peritoneal dissemination
- A condition in which cancers such as colorectal or stomach cancer have spread, as if scattered, to the membrane lining the abdominal cavity
NewsLab news
A student won an Outstanding Presentation Award at the 20th Medical and Pharmaceutical Sciences Symposium for Next-Generation Young Researchers
A master's student won an Outstanding Presentation Award at the 42nd Annual Meeting of the Japan Society of Drug Delivery System
A student won a Student Outstanding Presentation Award at the 146th Annual Meeting of the Pharmaceutical Society of Japan
Press release on research findings on the mechanism of anaphylaxis to antibody drugs
A master's student won an Outstanding Presentation Award at the master's thesis presentation session
ResearchResearch themes
The lab studies next-generation drugs centered on new treatment modalities such as immunotherapy and nucleic acid drugs. It focuses on how drugs move within the body and cells, specifically whether they reach the places where they are needed in an appropriate form, and carries out research that responds to clinical problems and questions.
*Illustrative imageEfficacy and pharmacokinetics of immune checkpoint inhibitors
The lab is investigating how antibodies that target the same pathway, such as anti-PD-1 and anti-PD-L1 antibodies, can differ in efficacy because of differences in their distribution and degradation in the body. It also analyzes how antibody properties affect efficacy and examines side effects using databases.
*Illustrative imageIntraperitoneal administration to deliver drugs to peritoneal dissemination
Using model mice, the lab has shown that antibody drugs given intravenously have difficulty reaching peritoneal dissemination. It studies how antibody drugs and anticancer drugs move after intraperitoneal administration, in which a drug is given directly into the abdominal cavity, and explores the characteristics of drugs that reach the target more easily.
*Illustrative imageDelivering nucleic acid drugs with lipid nanoparticles
The lab studies lipid nanoparticles that carry nucleic acid drugs into cells. Through intraperitoneal administration, it has delivered them efficiently to peritoneal dissemination and found particles whose mRNA acts in the peritoneal dissemination while avoiding the liver, and it is working toward therapeutic applications.
*Illustrative imageMechanisms of hypersensitivity to antibody drugs
Using cancer model mice, the lab investigates why anaphylaxis and infusion reactions occur after antibody drugs are administered. It searches for clues to prevention and treatment, and compares its findings with clinical trends using databases.
MembersFaculty
The members of the Drug Science Lab are the faculty, students in the doctoral, master's, and undergraduate programs, and visiting researchers.As of 2026
- ProfessorHiroto Hatakeyama
- Assistant ProfessorYuta Tamemoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Disposable Pipette Tips in Laboratory Tip Boxes” Gannu03 / CC BY-SA 4.0 (cropped)
- Efficacy and pharmacokinetics of immune checkpoint inhibitors: “Nivolumab 5GGR” Fvasconcellos (talk · contribs) / Public domain (cropped)
- Intraperitoneal administration to deliver drugs to peritoneal dissemination: “Chemotherapy vials (4)” Bill Branson (Photographer) / Public domain (cropped)
- Delivering nucleic acid drugs with lipid nanoparticles: “Liposome scheme RNA-es” SuperManu, Rowanwindwhistler / CC BY-SA 4.0 (cropped)
- Mechanisms of hypersensitivity to antibody drugs: “Adrenalina autoinyector9” AngelHM / CC BY-SA 4.0 (cropped)
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