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Clinical Pharmacotherapeutics Lab
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The lab examines how drugs work in each patient to find the optimal drug therapy.
AboutAbout the lab
Connecting the bench and the bedside to achieve optimal drug therapy
The Clinical Pharmacotherapeutics Lab conducts research aimed at optimizing drug therapy, meaning better ways of using drugs, and at generating new information on the effects and safety of drugs.
By combining "wet-lab research," which measures and analyzes drug concentrations, with "dry-lab research," which analyzes patient data, the lab tackles problems in clinical practice.
Under pharmacist faculty members who also hold posts at the University Hospital, the lab carries out clinically relevant research whose results can be returned to patients.
Through this research, the lab trains clinical pharmacists who can think about how to use drugs in a way that suits each individual patient.
Key terms
- Therapeutic drug monitoring (TDM)
- A method of measuring the concentration of a drug in the blood and adjusting the dose for each patient based on the result
- Pharmacokinetics
- What happens to a drug in the body: how it is absorbed, distributed throughout the body, broken down, and excreted
- Drug-resistant bacteria
- Bacteria that antibacterial drugs no longer work against. They can increase when drugs are used incorrectly
ResearchResearch themes
Using real patient data and test results, the lab clarifies changes in blood drug concentrations, predicts side effects, and identifies precautions for drug use, with the aim of optimizing drug therapy. The work combines "wet-lab research," which measures and analyzes drug concentrations, with "dry-lab research," which analyzes patient data.
*Illustrative imagePatient-tailored drug therapy
How well a drug works and what side effects it causes differ from patient to patient, depending on age, body size, kidney and liver function, concomitant drugs, and other factors. Using patient information from clinical practice, the lab investigates which drug, at what dose, is effective and safe for which patient.
*Illustrative imageDrug therapy in emergency and intensive care
In critically ill patients, changes in organ function and the use of ventilators and blood purification therapy make how drugs behave in the body (pharmacokinetics) very different from usual. The lab analyzes the pharmacokinetics of antibacterial and antifungal drugs to develop effective and safe dosing methods.
*Illustrative imageTherapeutic drug monitoring (TDM)
The lab studies how to determine the optimal dose from measured drug concentrations in the blood. It focuses on drugs for which dose adjustment is important, such as anti-infective drugs and anticancer drugs.
*Illustrative imagePharmaceutical research supporting infection treatment
If antibacterial and antifungal drugs are used incorrectly, they may not work sufficiently, and drug-resistant bacteria may increase. The lab examines how these drugs behave in the body in patients with severe infections or weakened immunity, and studies more effective treatment methods.
MembersFaculty
The members of the Clinical Pharmacotherapeutics Lab are faculty members, graduate students, and undergraduate students.As of 2026
- ProfessorShingo Yamazaki
- Project Assistant ProfessorHitomi Motomura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “New pharmacy for Guy's Hospital - geograph.org.uk - 4259421” Stephen Craven / CC BY-SA 2.0 (cropped)
- Patient-tailored drug therapy: “US Navy 030819-N-9593R-082 Pharmacist Randal Heller, right, verifies the dosage and medication of a prescription at the National Naval Medical Center in Bethesda, Maryland” U.S. Navy photo by Chief Warrant Officer 4 Seth Rossman. / Public domain (cropped)
- Drug therapy in emergency and intensive care: “20250808 Intensive care unit bed” Ismael Olea / CC BY 4.0 (cropped)
- Therapeutic drug monitoring (TDM): “Tube with blood sample” Dotodot / CC BY-SA 4.0 (cropped)
- Pharmaceutical research supporting infection treatment: “Antimicrobial susceptibility testing (AST) result of Leuconostoc” Ajay Kumar Chaurasiya / CC0 (cropped)
- Related lab (Clinical Pharmaceutics Lab): “Hospital Pharmacy” User:Mattes / Public domain (cropped)
- Related lab (Theoretical Drug Discovery Lab): “CSIRO ScienceImage 1788 Molecular model of a protein” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (Drug Science Lab): “Disposable Pipette Tips in Laboratory Tip Boxes” Gannu03 / CC BY-SA 4.0 (cropped)
- Related lab (Pharmacy Practice Lab): “Julie Zinihite at the pharmacy at the National Referal Hospital in Honiara, Solomon Islands 2012. Photo- AusAID ( )” Department of Foreign Affairs and Trade / CC BY 2.0 (cropped)
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