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Molecular Imaging Pharmaceutics Lab
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The lab combines radiation and drugs to develop agents that detect and treat cancer.
AboutAbout the lab
Detecting and treating cancer with radiation and drugs.
The Molecular Imaging Pharmaceutics Lab studies the development of radiopharmaceuticals, which are drugs that use radionuclides (RI).
Depending on the type of radiation used, a radiopharmaceutical can serve either as a diagnostic agent that detects disease through imaging or as a therapeutic agent that treats cancer.
For early diagnosis of cancer and early assessment of treatment effects, the lab is developing drugs that allow changes inside cells to be captured in images from outside the body.
In collaboration with Osaka University and other institutions, the lab is also working on developing cancer therapeutics that use astatine-211, which emits alpha radiation.
Key terms
- Radionuclide
- An atom that emits radiation as it changes into a different atom. Also called an RI (radioisotope)
- Alpha radiation
- A type of radiation that travels only a short distance and delivers a large amount of energy along the way
- Antibody
- A protein in the body that recognizes and binds to a specific target (antigen). This research uses small fragments of antibodies
NewsLab news
A student won the Young Investigator Excellent Presentation Award and the Poster Award at the 63rd Annual Meeting on Radioisotopes and Radiation Research
A master's student won the Outstanding Presentation Award at the master's thesis presentation session
A doctoral student's paper was accepted by Results in Chemistry
A student's paper was accepted by Nuclear Medicine and Biology
ResearchResearch themes
The lab synthesizes radiopharmaceuticals for cancer diagnosis and treatment using organic reactions, and evaluates them through cell experiments and biodistribution studies in animals. It currently focuses on two areas: research on reducing the kidney accumulation of drugs based on small antibody fragments, and the development of alpha-particle therapeutics using astatine-211.
*Illustrative imageAntibody-based drugs that do not accumulate in the kidneys
Small antibody fragments labeled with RI stay in the kidneys for a long time, which lowers imaging accuracy and can cause kidney toxicity. The lab is developing drug designs in which an enzyme on the membrane of kidney cells cleaves the drug into a form that is easily excreted in urine, and aims to apply them to other radionuclides and molecules.
*Illustrative imageAlpha-particle therapeutics using astatine-211
With conventional drugs, astatine-211, which emits alpha radiation, tended to detach in the body and accumulate in organs such as the stomach and spleen. The lab is developing labeling structures that are less prone to detaching and combining them with molecules that accumulate in cancer, aiming to create highly effective therapeutics with fewer side effects.
MembersFaculty
The members of the Molecular Imaging Pharmaceutics Lab consist of faculty members and doctoral, master's, and undergraduate students.As of 2026
- ProfessorTomoya Uehara
- LecturerHiroyuki Suzuki
- Assistant ProfessorKento Kannaka
- Assistant ProfessorNobuki Kazuta
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PET-CT-Philips” Partynia / CC BY-SA 4.0 (cropped)
- Antibody-based drugs that do not accumulate in the kidneys: “Pipette gallery” User:Squidonius, myself, and User:Beliason (assumed). / CC BY-SA 4.0 (cropped)
- Alpha-particle therapeutics using astatine-211: “Radio-Chemist closing a hot cell to proect themselves from radiation” Talzir / CC BY-SA 4.0 (cropped)
- Related lab (Synthetic Medicinal Chemistry Lab): “Molecular model of the pre-pore form of a MACPF protein based upon the structure of pneunolysin” Jcwhizz at English Wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (Pharmacodynamics Lab): “Fluorescence.microscope2” Bioguy10 / CC0 (cropped)
- Related lab (Theoretical Drug Discovery Lab): “CSIRO ScienceImage 1788 Molecular model of a protein” division, CSIRO / CC BY 3.0 (cropped)
- Related lab (Pharmaceutical Physical Chemistry Lab): “TMEM171 Structure Model” Bauma319 / CC BY-SA 4.0 (cropped)
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