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23 labs · 0 student voices
Faculties at Kyushu University ›
Yasuyuki Ohkawa, Professor
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The Ohkawa Lab studies how the genes that define a cell's identity are selected from the genome, focusing on chromatin structure. While examining the differentiation potential of stem cells in terms of chromatin structure, the lab aims to understand it by computationally analyzing epigenome data. The lab works systematically, from developing single-cell analysis technologies using high-throughput sequencers to developing technologies for analyzing large-scale data. On the lab's website, it is presented under the name "Ohkawa Lab, Division of Transcriptomics."
Hiroyuki Kubota, Professor
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The Integrative Omics Lab studies life by reading and understanding it as "a large-scale information network spanning multiple layers." By closely coordinating experiments with computational analysis, the lab pursues trans-omics analysis, which reconstructs networks from multilayered data. Focusing on obesity, the lab investigates how obesity becomes a risk factor for various diseases and what blood insulin patterns mean. On the lab's website, it is presented under the name "Division of Integrative Omics."
Takahiro Masuda, Professor
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The Molecular Neuroimmunology Lab focuses on immune cells found inside the brain and at its borders, and studies brain physiology and disease. Its research theme is to clarify how brain macrophages, such as microglia and CNS-associated macrophages (CAMs), develop and why they exist. The faculty's research topics also include understanding brain physiology and disease starting from lipid metabolism, and the role of CNS-associated macrophages in stroke. On the lab's website, it is introduced under the name "Masuda Lab."
Akiyoshi Uezumi, Professor
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The Cell Heterogeneity Lab studies the mechanisms that keep skeletal muscle in a healthy state, and the significance of heterogeneity among mesenchymal stromal cells. Its listed research keywords are skeletal muscle, mesenchymal stromal cells, sarcopenia, muscle regeneration, and stem cells. The lab belongs to the Center for Deep Omics Science, affiliated with the Medical Institute of Bioregulation.
Hiroshi Ochiai, Professor
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The Gene Expression Dynamics Lab, at the Center for Deep Omics Science of the Medical Institute of Bioregulation, studies how transcriptional bursting is regulated. Using mouse early embryos, in vivo systems, and embryonic stem (ES) cells as models, the lab applies techniques such as live imaging, multimodal spatial omics, and genome editing. The lab also investigates how the diversity in gene expression that accompanies transcriptional bursting affects cell fate determination. Another research target is the mechanism by which differences in gene expression levels between cells increase with aging.
Masao Nagasaki, Professor
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The Biomedical Information Analysis Lab uses data science techniques to analyze large-scale human data such as genomes and omics. The lab develops analysis methods and software suited to measurement instruments, and builds systems that use cohort and clinical specimen data for disease research. Through its research, the lab is also training people for the data science era who can analyze human genome, omics, and clinical data. On the lab's website, it is introduced under the name "Nagasaki Lab."
Kosuke Tomimatsu, Associate Professor
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The Disease Genome Biology Lab studies cellular senescence, epigenetics, and chromatin at the High-Depth Omics Science Center of the Medical Institute of Bioregulation. Its research themes also include developing spatial multi-omics methods at single-cell resolution. A 2021 paper with Associate Professor Kosuke Tomimatsu as first author reported that during cellular senescence, some genes become active in heterochromatin regions.
Mikita Suyama, Professor
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The Information Biology Lab studies the mechanisms that switch gene expression ON and OFF, and their evolution. Because gene expression switches tend to be conserved through evolution, they can be found by comparing the genome sequences of various animals such as humans and mice. In addition to genome sequences, the lab integrates and analyzes tissue-specific gene expression data and information on genome modifications, aiming to clarify the details of regulatory mechanisms and their evolution. The lab hopes to apply its findings to clarifying the causes of diseases thought to arise from abnormal regulation of gene expression.
Shinichiro Sawa, Professor
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The Mucosal Defense Lab comprehensively investigates the cells that make up intestinal tissue and their functions, aiming for an integrated understanding of the intestinal immune system. Mucosal surfaces such as those of the respiratory and digestive tracts are sites in broad contact with the external environment, and they are also the main entry routes for pathogens and allergens. The intestine hosts many coexisting gut bacteria, which are known to be involved in the maturation of the immune system and in metabolism. The lab carries out its research in collaboration with research institutions inside and outside the institute.
Yuma Ito, Assistant Professor
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The Joint Research Division of Deep Omics Analysis at the Medical Institute of Bioregulation develops spatial omics technologies that simultaneously capture where each cell is located in a tissue and what it expresses. The lab works on a method that combines a technique for writing positional information into cells as molecular barcodes with single-cell gene expression analysis, reconstructing tissue as a spatial map of single cells. The lab is also developing a technology that simultaneously visualizes chemical modifications of RNAs and proteins inside cells, and uses AI image analysis to investigate where in the cell RNAs that disrupt normal cell function act.
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