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Mucosal Defense Lab
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The lab studies how immune cells in the intestine function.
AboutAbout the lab
Exploring the big picture of immunity through intestinal cells and their functions.
The Mucosal Defense Lab comprehensively investigates the cells that make up intestinal tissue and their functions, aiming for an integrated understanding of the intestinal immune system.
Mucosal surfaces such as those of the respiratory and digestive tracts are sites in broad contact with the external environment, and they are also the main entry routes for pathogens and allergens.
The intestine hosts many coexisting gut bacteria, which are known to be involved in the maturation of the immune system and in metabolism.
The lab carries out its research in collaboration with research institutions inside and outside the institute.
Key terms
- Mucosa
- Tissue in broad contact with the external environment, such as that of the respiratory and digestive tracts.
- Innate lymphoid cells (ILCs)
- A group of lymphocytes that lack antigen receptors. They mediate early immune responses in mucosal tissues.
- RORγt
- A protein that regulates gene activity (a transcription factor). ILC3s depend on it for their differentiation.
NewsLab news
Paper on how bone marrow forms inside bone accepted by Nature Communications
Differentiation control of innate immune cells by the transcription factor RORγt elucidated; paper published in Immunity
Maintenance mechanism of intestinal macrophages elucidated; paper accepted by Mucosal Immunology
ResearchResearch themes
In the lamina propria of the intestine, immune cells and neurons form a complex network, and the epithelium has its functions modulated by signals from the cells there. The lab comprehensively analyzes the cells that make up intestinal tissue and their functions, aiming for an integrated understanding of the intestinal immune system.
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MembersFaculty
The members of the Mucosal Defense Lab consist of faculty, doctoral students, collaborative researchers, commissioned researchers, and technical staff.As of 2026
- ProfessorShinichiro Sawa
- Assistant ProfessorTaisho Yamada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell-1” Mk4716 / CC BY-SA 4.0 (cropped)
- Differentiation and Function of Innate Lymphoid Cells: “Intestinal villi through microscope” Jamil Baza / CC BY 4.0 (cropped)
- Related lab (Information Biology Lab): “Gene co-expression network with 7221 genes for 18 gastric cancer patients” S. Mohammad H. Oloomi / CC BY-SA 3.0 (cropped)
- Related lab (Molecular Neuroimmunology Lab): “Fluorescently Labeled Microglia in a Mouse Brain Section” Syed07 / CC BY 4.0 (cropped)
- Related lab (Immune Genome Biology Lab): “Normal Lymph Node” Ed Uthman, MD / CC BY-SA 2.0 (cropped)
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