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Gene Expression Dynamics Lab
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The lab tracks the mechanisms of transcriptional bursting in living cells.
AboutAbout the lab
Watching the dynamics of gene expression in living cells
The Gene Expression Dynamics Lab, at the Center for Deep Omics Science of the Medical Institute of Bioregulation, studies how transcriptional bursting is regulated.
Using mouse early embryos, in vivo systems, and embryonic stem (ES) cells as models, the lab applies techniques such as live imaging, multimodal spatial omics, and genome editing.
The lab also investigates how the diversity in gene expression that accompanies transcriptional bursting affects cell fate determination.
Another research target is the mechanism by which differences in gene expression levels between cells increase with aging.
Key terms
- Transcriptional bursting
- A phenomenon in which the production of RNA from a gene switches between a highly active state and a nearly inactive state.
- Live imaging
- A method of observing the movement of molecules and genes inside living cells over time under a microscope.
- Spatial omics
- An approach that comprehensively examines the state of genes and molecules while preserving their positions within cells and tissues.
NewsLab news
Joint research with the National Institute of Genetics published in Nature Genetics
Preprint on the link between chromatin modifications and transcriptional bursting released on bioRxiv
Review article summarizing the visualization of transcriptional bursting by RNA imaging published in the monthly journal Saibo
Paper on gene expression regulation through changes in the distance between genes published in Science Advances
Image analysis protocol for DNA/RNA/IF-seqFISH published in Methods Mol. Biol.
ResearchResearch themes
Gene activity is controlled mainly by transcription. Using mouse early embryos, in vivo systems, and embryonic stem (ES) cells, the lab addresses the regulation of transcriptional bursting, gene expression diversity and cell fate determination, and aging and diversity in gene expression levels.
*Illustrative imageRegulatory mechanisms of transcriptional bursting
The lab aims to clarify how transcriptional bursting is regulated. It uses advanced techniques such as live imaging and genome editing.
*Illustrative imageGene expression diversity and cell fate
The lab investigates how the diversity in gene expression that arises with transcriptional bursting affects the process by which cell fate is determined.
*Illustrative imageAging and differences in expression levels between cells
The lab aims to clarify the mechanism by which differences in gene expression levels between cells, which increase with aging, arise.
MembersFaculty
The members of the Gene Expression Dynamics Lab consist of faculty, academic researchers, doctoral and master's students, technical staff, and administrative assistants.As of 2026
- ProfessorHiroshi Ochiai
- Assistant ProfessorYoshiaki Kobayashi
- Assistant ProfessorSatoshi Uchino
- Assistant Professor (Specially Appointed Project Faculty)Michiko Suma
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “TranscriptionGraphic PublicDomain” Zulujive / CC0 (cropped)
- Regulatory mechanisms of transcriptional bursting: “Basic diagram of locations of gene expression” NHS National Genetics and Genomics Education Centre / CC BY 2.0 (cropped)
- Gene expression diversity and cell fate: “Single Cell RNA Seq (NIH BioArt 767)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Aging and differences in expression levels between cells: “The Hallmarks of Aging” Rebelo-Marques, De Sousa Lages, Andrade, Ribeiro, Mota-Pinto, Carrilho and Espregueira-Mendes / CC BY 4.0 (cropped)
- Related lab (バイオメディカル情報解析): “Geographical distribution of human major genetic ancestral components” Wikiuser1314 / CC BY-SA 4.0 (cropped)
- Related lab (疾患ゲノム生物学): “Histological section of small intestine epithelial tissue, zoom” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Related lab (トランスクリプトミクス): “Chromatin Structures” Original uploader was Richard Wheeler at en.wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (細胞不均一性学): “Skeletal Muscle Tissue” Community College Bioscience / CC0 (cropped)
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