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Information Biology Lab
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The lab explores the regulation and evolution of gene expression from genome information.
AboutAbout the lab
Comparing genomes to find the switches of gene expression
The Information Biology Lab studies the mechanisms that switch gene expression ON and OFF, and their evolution.
Because gene expression switches tend to be conserved through evolution, they can be found by comparing the genome sequences of various animals such as humans and mice.
In addition to genome sequences, the lab integrates and analyzes tissue-specific gene expression data and information on genome modifications, aiming to clarify the details of regulatory mechanisms and their evolution.
The lab hopes to apply its findings to clarifying the causes of diseases thought to arise from abnormal regulation of gene expression.
Key terms
- Intratumor heterogeneity
- A state in which, even within the cancer of a single patient, the combination of gene mutations differs from cell to cell
- Exon
- A region within a gene that specifies the amino acid sequence
- Intron
- A region within a gene that does not specify the amino acid sequence
NewsLab news
Paper on nonsense-mediated mRNA decay published in Nucleic Acids Research
A paper by a doctoral student has been accepted
A paper by a doctoral student has been accepted
ResearchResearch themes
The lab investigates the mechanisms that switch gene expression ON and OFF, and their evolution, through computational analyses such as genome sequence comparison. It aims to apply its findings to clarifying the causes of diseases thought to arise from abnormal gene expression regulation.
*Illustrative imageExploring evolutionary paths of cancer
The lab uses large-scale data and statistical methods to analyze how intratumor heterogeneity, in which the combination of gene mutations differs from one cancer cell to another, forms and evolves. Cells with drug resistance may lead to cancer recurrence.
*Illustrative image3D chromosome structure and gene expression
Focusing on the relationship between the three-dimensional structure of chromosomes and transcriptional regulation, the lab aims to identify the mechanisms by which new diseases develop. It also searches, by comparing across species, for differences in gene expression regulation that can explain differences between species.
*Illustrative imageSearching for phenomena in which new exons become active
Cases have been reported in which mutations in introns, which do not specify amino acid sequences, activate new exons and cause disease. The lab comprehensively searches for this phenomenon using bioinformatics methods.
*Illustrative imageRegulation and evolution of splicing
Most eukaryotic genes produce multiple transcripts from a single gene locus through alternative splicing. To elucidate its regulatory mechanisms and molecular evolution, the lab is conducting comparative genomic analyses of mutually exclusive splicing.
MembersFaculty
The members of the Information Biology Lab consist of faculty members, doctoral and master's students, and collaborative researchers.As of 2026
- ProfessorMikita Suyama
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Gene co-expression network with 7221 genes for 18 gastric cancer patients” S. Mohammad H. Oloomi / CC BY-SA 3.0 (cropped)
- Exploring evolutionary paths of cancer: “Cancer pharmacogenomics” Alejoaguia / CC BY-SA 4.0 (cropped)
- 3D chromosome structure and gene expression: “Chromatin and chromatin with nucleosome eviction” MethylC5 / CC0 (cropped)
- Searching for phenomena in which new exons become active: “Messenger RNA maturation” Kep17 / CC BY-SA 4.0 (cropped)
- Regulation and evolution of splicing: “HAC mRNA” Kbhooks / CC BY-SA 3.0 (cropped)
- Related lab (Mucosal Defense Lab): “Cell-1” Mk4716 / CC BY-SA 4.0 (cropped)
- Related lab (Nakatani Higher-Order Life Dynamics Lab): “Epigenetische Mechanismen” File:Epigenetic mechanisms.png: National Institutes of Health derivative work: Henry Sonnet / CC0 (cropped)
- Related lab (Integrative Omics Lab): “Multichannel pipette-12” real name: Nadina Wiórkiewicz pl.wiki: Nadine90 commons: Nadine90 / CC BY-SA 3.0 (cropped)
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