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Disease Genome Biology Lab
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The lab studies cellular senescence, chromatin, and spatial multi-omics methods.
AboutAbout the lab
Exploring changes in cellular senescence and chromatin
The Disease Genome Biology Lab studies cellular senescence, epigenetics, and chromatin at the High-Depth Omics Science Center of the Medical Institute of Bioregulation.
Its research themes also include developing spatial multi-omics methods at single-cell resolution.
A 2021 paper with Associate Professor Kosuke Tomimatsu as first author reported that during cellular senescence, some genes become active in heterochromatin regions.
Key terms
- Chromatin
- A structure in the cell nucleus in which DNA is folded together with proteins
- Heterochromatin
- A region of chromatin that is especially condensed, where gene activity tends to be repressed
- Cellular senescence
- A phenomenon in which cells become fixed in a particular state, accompanied by reorganization of heterochromatin
- Spatial multi-omics
- A method for examining multiple types of molecules while preserving information on their position within tissue
ResearchResearch themes
The Disease Genome Biology Lab lists cellular senescence, epigenetics, and chromatin as its research themes. It is also working on developing spatial multi-omics methods at single-cell resolution.
*Illustrative imageCellular senescence and chromatin changes
In cellular senescence, heterochromatin is reorganized. A 2021 paper with Associate Professor Tomimatsu as first author reports that some genes begin to be active in regions that had been repressed.
Developing single-cell spatial multi-omics methods
The lab is developing spatial multi-omics methods at single-cell resolution. A 2024 paper with Associate Professor Tomimatsu as first author reports a method that uses antibodies with cleavable fluorescent labels to take images in sequence with many antibodies.
MembersFaculty
- Associate ProfessorKosuke Tomimatsu
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histological section of small intestine epithelial tissue, zoom” Otávio Astor Vaz Costa / CC BY 4.0 (cropped)
- Cellular senescence and chromatin changes: “Cellular senescence” Velichko Artem / CC BY 4.0 (cropped)
- Related lab (トランスクリプトミクス): “Chromatin Structures” Original uploader was Richard Wheeler at en.wikipedia / CC BY-SA 3.0 (cropped)
- Related lab (細胞不均一性学): “Skeletal Muscle Tissue” Community College Bioscience / CC0 (cropped)
- Related lab (遺伝子発現動態学): “TranscriptionGraphic PublicDomain” Zulujive / CC0 (cropped)
- Related lab (分子神経免疫学): “Fluorescently Labeled Microglia in a Mouse Brain Section” Syed07 / CC BY 4.0 (cropped)
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