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Yamasaki Lab
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A lab exploring how immune receptors detect abnormalities in the body.
AboutAbout the lab
Exploring how immune receptors detect foreign invaders and abnormalities in the body
The Yamasaki Lab studies immune receptors, which, within the immune system that protects the body, detect the invasion of foreign pathogens and abnormalities in the body.
The lab has identified members of the lectin receptor family that recognize pathogens and damaged self components, and was the first to discover a group of receptors that recognize components of Mycobacterium tuberculosis.
It also studies how T cells are selected in the thymus and how T cells respond to SARS-CoV-2.
Key terms
- Immune receptor
- A receptor of the immune system that rapidly detects the invasion of foreign pathogens and abnormalities in the body
- Lectin receptor
- A family of receptors that recognize pathogens and damaged self components
- T cell receptor
- A receptor on T cells that is involved in selection in the thymus. Abbreviated TCR
NewsLab news
A doctoral student won a Poster Award at the 27th Immunology Summer School
A master's student was selected for the Osaka University Outstanding Research Award for Female Graduate Students
Doctoral and master's students won the Ikuya Yano Award at the 14th ITAM Workshop
A doctoral student won the Best Presentation Award at the 54th Annual Meeting of the Japanese Society for Immunology
Discovery of a new mechanism that regulates NKT cell differentiation
ResearchResearch themes
The Yamasaki Lab studies immune receptors, which, within the immune system that protects the body, rapidly detect the invasion of foreign pathogens and abnormalities in the body. The lab aims to apply these findings to efficiently activating immunity and to treating diseases caused by excessive immune responses.
*Illustrative imageRecognition of foreign substances by lectin receptors
The lab has identified members of the lectin receptor family that recognize pathogens and damaged self components, and investigates how they distinguish foreign substances and why this matters. It seeks to apply the findings to immune activation and to the treatment of diseases caused by excessive immune responses.
*Illustrative imageT cell differentiation and self-discrimination
Cells in the thymus combine lenient and stringent selection to generate a population of T cell receptors that has both diversity and specificity. The lab seeks to clarify by what molecular mechanisms the body controls these two selection steps.
*Illustrative imageT cell responses to SARS-CoV-2
Through single-cell analysis, the lab found a T cell clone that commonly expands in patients with mild COVID-19 who have recovered. The region of the spike protein that this clone recognizes is conserved in variant strains, making it a candidate antigen for booster vaccines.
MembersFaculty
The Yamasaki Lab's members consist of faculty, project researchers, project technical staff, doctoral and master's students, secretaries, and visiting faculty and researchers.As of 2026
- ProfessorSho Yamasaki
- Associate ProfessorNorikazu Yabuta
- LecturerEri Ishikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Macrophage (NIH BioArt 311)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Recognition of foreign substances by lectin receptors: “PAMPs and PRRs in the Innate Immune System” Immcarle105 / CC BY-SA 4.0 (cropped)
- T cell differentiation and self-discrimination: “1FYT T-cell receptor and HLA class II complex” Takuma-sa / CC0 (cropped)
- T cell responses to SARS-CoV-2: “Novel Coronavirus SARS-CoV-2” NIAID-RML (https://www.niaid.nih.gov/ & https://www.niaid.nih.gov/about/rocky-mountain-laboratories) / CC BY 2.0 (cropped)
- Related lab (自然免疫学分野 審良研究室): “Toll-Like Receptors (TLRs)” Varun Punnam / CC BY-SA 4.0 (cropped)
- Related lab (免疫化学分野 荒瀬研究室): “Cytotoxic T cell-ja” Template drawing and caption text from "The Immune System", any modifcations made by myself, are released into the public domain.; tossh_eng for ja label. / CC BY-SA 3.0 (cropped)
- Related lab (代謝免疫学グループ): “Macrophage (NIH BioArt 312)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (糖鎖免疫学グループ): “CSIRO ScienceImage 354 Influenza Protein Attaching to Cell Membrane” Health Sciences and Nutrition, CSIRO / CC BY 3.0 (cropped)
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