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Cell Systems Lab
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The lab uses experiments and mathematics to decipher molecular networks inside cells.

AboutAbout the lab
Deciphering cellular networks with experiments and mathematics.
The Cell Systems Lab studies the relationship between cellular networks and the control of cell fate, focusing on the amounts, interactions, and changes over time of molecules inside cells.
Combining quantitative experiments, mathematical models, and omics data analysis, the lab investigates the mechanisms that determine cell fate in cancer, the immune system, and the brain.
The starting question is how cells select and process the necessary information from among many genes.
On the lab's website, it is introduced under the name "Okada Lab."
Key terms
- Signal transduction
- The mechanism by which a cell receives information from outside and relays it inside, from one molecule to the next
- Omics
- A general term for methods that comprehensively examine the molecules inside cells, such as genes, RNA, and proteins
- Transcriptome
- The entire set of RNA produced from genes inside a cell. There are also methods to examine it cell by cell
NewsLab news
Co-authored paper published in Current Opinion in Cell Biology
Paper on the G1/S transition of the cell cycle published in Journal of Biological Chemistry
Paper on deep learning modeling of the epigenome published in Genes to Cells
Paper on intracellular signaling analysis published in Bioinformatics Advances
Paper on cellular senescence published in The FEBS Journal
ResearchResearch themes
The molecular mechanisms that determine cell fate can be pictured as a network, like an electrical circuit connecting proteins, RNA, and DNA. The lab combines experiments, mathematical models, and omics data analysis to clarify how this is regulated, focusing on cancer, the immune system, and the brain.
*Illustrative imageErbB receptor signaling and cell regulation
The lab studies the relationship between the ErbB receptor signal transduction system and cell regulation. The topics are control of the cell cycle and regulation of immediate early genes.
NF-kB signaling and cell regulation
The lab studies the relationship between the NF-kB signal transduction system and cell regulation. The topics are regulation of immune cells and aging.
Building frameworks for mathematical modeling and analysis
The lab builds analysis frameworks for mathematical modeling and bioinformatics. Specific examples include patient-specific models and cancer classification, natural language processing that builds mathematical models from text, and analysis tools for single-cell transcriptomes and epigenomes.
MembersFaculty
The members of the Cell Systems Lab consist of faculty, researchers, staff, and doctoral and master's students.As of 2026
- ProfessorMariko Okada
- Associate ProfessorKeita Iida
- Project LecturerKayo Hibino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Fluorescence micrograph of Thalassiosira nanae” Terry J. McGenity, Amare Gessesse, John E. Hallsworth, Esther Garcia Cela, Carol Verheecke-Vaessen, Fengping Wang, Max Chavarría, Max M. Haggblom, Søren Molin, Antoine Danchin, Eddy J. Smid, Cédric Lood, Charles S. Cockell, Corinne Whitby, Shuang-Jiang Liu, Nancy P. Keller, Lisa Y. Stein, Seth R. Bordenstein, Rup Lal, Olga C. Nunes, Lone Gram, Brajesh K. Singh, Nicole S. Webster, Cindy Morris, Sharon Sivinski, Saskia Bindschedler, Pilar Junier, André Antunes, Bonnie K. Baxter, Paola Scavone and Kenneth Timmis Photograph by Philippe Laissue. / CC BY-SA 4.0 (cropped)
- ErbB receptor signaling and cell regulation: “Signal transduction pathways zh” File:Signal transduction pathways.png: Boghog2 at English Wikipedia derivative work: GnolizX / Public domain (cropped)
- Related lab (Cell Function Design Lab): “Synthetic Biology Research at NASA Ames” Alexander van Dijk from San Francisco, United States / CC BY 2.0 (cropped)
- Related lab (Membrane Systems Biology Lab): “Plasma membrane structure diagram” Rosanna Hartline (RosieScienceGal) / CC BY 4.0 (cropped)
- Related lab (Computational Biology Lab): “Linuron-3D-molecular-model-engraved-render-CAS-330-55-2” MolGod Scientific / CC BY-SA 4.0 (cropped)
- Related lab (Biomolecular Dynamics Modeling Lab): “TriosePhosphateIsomerase Ribbon pastel” Dcrjsr / CC BY 3.0 (cropped)
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