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Chikashi Obuse, Professor
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The Chromosome Structure and Function Lab studies at the molecular level how genetic information is packaged in the nucleus, inherited, and regulated in its expression. DNA, the blueprint that builds the body, is a long molecule that reaches about 2 meters in humans, yet it fits inside a nucleus about 10 µm in diameter. This molecule is accurately passed on to tens of trillions of cells, and its expression is tightly regulated as the body develops. The lab's research results page introduces papers on the regulation of stem cell differentiation and the repair of broken DNA.

Naotada Ishihara, Professor
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The Cellular Life Science Lab studies the "dynamics" of mitochondria, which change shape through fusion and fission. The lab approaches the topic from two sides: the molecular mechanisms that change membrane shape, and the significance of these processes, including their roles in a healthy body and their effects in disease. The lab combines cell culture experiments, biochemical experiments using isolated mitochondria and purified proteins, and experiments involving mouse genes. On the lab's website, it is introduced as the "Ishihara Lab."

Takuro Nakagawa, Professor
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The Molecular Genetics Lab studies how chromosomes, which carry genetic information, are kept stable and accurately passed on to daughter cells. Inside the cell nucleus, DNA binds to histones to form nucleosomes, which are further organized into higher-order chromatin structures. The lab aims to clarify the molecular mechanisms by which reactions on chromosomes, such as DNA replication, recombination, repair, transcription, and chromatin regulation, work together to maintain chromosome stability. The lab uses fission yeast and cultured human cells in its research.

Yoshitaka Matsuo, Professor
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The Dynamic Molecular Biochemistry Lab focuses on translation, the endpoint of the central dogma, and studies the dynamic process by which nascent chains produced by translation mature into functional proteins. The lab also explores how giant molecular complexes such as the ribosome are assembled with precision inside the cell. Focusing on quality control mechanisms, the lab investigates how translation becomes more prone to stalling with aging, leading to the accumulation of abnormal proteins. The lab combines multi-omics, in vitro reconstitution systems, high-speed AFM, cryo-EM, and other analyses in its research.

Takahide Kon, Professor
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The Cell Architecture Lab studies intracellular transport, the mechanism that delivers what is needed to where it is needed, at the time it is needed, inside the cell. The lab is a group of researchers specializing in structural biology, protein science, and cell biology, who investigate the topic from many angles at the levels of molecular structure, supramolecular complexes, and the cell. The lab's website says it focuses on the working mechanism of dynein, a giant protein nanomachine that plays an important role in transport in the brain and nervous system. At the undergraduate level, the lab mainly accepts fourth-year students of the Department of Biological Sciences as graduation research students. Note that the news items and member list on the lab website date from around 2018.

Yumiko Kubota, Associate Professor
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The Interdisciplinary Group (Nuclear Function) studies the mechanisms by which chromosomal DNA is replicated. The lab's website lists "replication licensing," which ensures that chromosomal DNA is replicated only once per cell cycle, as one of the pillars of its research. In addition to studying replication from the perspectives of making, transmitting, and protecting chromosomes, the lab also lists the development of the "protein interference method," which degrades target proteins to study their functions.

Kaoru Imai, Associate Professor
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The Interdisciplinary Group (Developmental Biology) is a lab in the Department of Biological Sciences, Graduate School of Science, Osaka University, that studies developmental biology. It belongs to the Cell Biology Division, and Associate Professor Kaoru Imai is listed as a faculty member. The lab is located on the Toyonaka Campus.

Tetsuhiro Asada, Assistant Professor
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The Interdisciplinary Group (Plant Science) aims to clarify how patterns arise during plant growth. Simple, regular biological patterns, such as the arrangement of leaves and of cells, have long attracted scientists and are still actively studied. At the tissue level, the lab focuses on how the cell division plane is selected; at the whole-plant level, it studies a perennial herbaceous plant characterized by the plasticity of its phyllotaxis.

Shinobu Takada, Assistant Professor
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The Biological Sciences Group (Plant Positional Information) conducts research with the goal of uncovering the positional information that operates in early plant embryos. Organs of a seedling, such as the cotyledons and roots, are always formed in fixed arrangements. The lab investigates how cells recognize where they are and activate genes accordingly. Using the model plant Arabidopsis thaliana, the lab carries out analyses with reverse genetics approaches that make use of genome information. The lab welcomes undergraduate and graduate students who would like to work on research together.

Tetsuro Hirose, Professor
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The RNA Biofunction Lab studies the functions of noncoding RNAs that serve as the scaffold of intracellular structures, among the large numbers of noncoding RNAs produced from the human genome. The lab discovered these RNAs and named them architectural RNAs (arcRNAs). Together with proteins, arcRNAs cause intracellular phase separation and lead the formation of membraneless organelles. The lab investigates how proteins recognize arcRNA sequences, how arcRNAs function, and how to find new arcRNAs, through three research themes. On the lab's website, it is introduced as a lab of the Graduate School of Frontier Biosciences, Osaka University.
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